Inhibitory effect of prolactin on ovulation in the in vitro perfused rabbit ovary

Yasuo Hamada; Sheldon Schlaff; Yoshimune Kobayashi; Rosie Santulli; Karen H. Wright; Edward E. Wallach

doi:10.1038/285161a0

Inhibitory effect of prolactin on ovulation in the in vitro perfused rabbit ovary

Yasuo Hamada, Sheldon Schlaff, Yoshimune Kobayashi, Rosie Santulli, Karen H. Wright, Edward E. Wallach

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

Prolactin is best known for its effects on the breast, promoting mammary growth and lactation. In some species, including rat, mouse, hamster, sheep and rabbit, prolactin is necessary for the maintenance of the corpus luteum ^1-5. Further, a relationship has been recognised between hyperprolactinaemia and ovulatory failure in the human. The site of action is thought to be the hypothalamus and or adenohypophysis⁶. McNatty et al.⁷ have postulated a direct ovarian effect of prolactin, reporting that low prolactin levels were essential for progesterone production by preovulatory human granulosa cells cultured in vitro. However, high levels of prolactin decreased progesterone production. The present investigation sought to determine the effect of prolactin on ovulation using the in vitro perfused rabbit ovary preparation. We report that its effects are inhibitory.

Original language	English (US)
Pages (from-to)	161-163
Number of pages	3
Journal	Nature
Volume	285
Issue number	5761
DOIs	https://doi.org/10.1038/285161a0
State	Published - 1980
Externally published	Yes

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title = "Inhibitory effect of prolactin on ovulation in the in vitro perfused rabbit ovary",

abstract = "Prolactin is best known for its effects on the breast, promoting mammary growth and lactation. In some species, including rat, mouse, hamster, sheep and rabbit, prolactin is necessary for the maintenance of the corpus luteum 1-5. Further, a relationship has been recognised between hyperprolactinaemia and ovulatory failure in the human. The site of action is thought to be the hypothalamus and or adenohypophysis6. McNatty et al.7 have postulated a direct ovarian effect of prolactin, reporting that low prolactin levels were essential for progesterone production by preovulatory human granulosa cells cultured in vitro. However, high levels of prolactin decreased progesterone production. The present investigation sought to determine the effect of prolactin on ovulation using the in vitro perfused rabbit ovary preparation. We report that its effects are inhibitory.",

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T1 - Inhibitory effect of prolactin on ovulation in the in vitro perfused rabbit ovary

AU - Hamada, Yasuo

AU - Schlaff, Sheldon

AU - Kobayashi, Yoshimune

AU - Santulli, Rosie

AU - Wright, Karen H.

AU - Wallach, Edward E.

PY - 1980

Y1 - 1980

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AB - Prolactin is best known for its effects on the breast, promoting mammary growth and lactation. In some species, including rat, mouse, hamster, sheep and rabbit, prolactin is necessary for the maintenance of the corpus luteum 1-5. Further, a relationship has been recognised between hyperprolactinaemia and ovulatory failure in the human. The site of action is thought to be the hypothalamus and or adenohypophysis6. McNatty et al.7 have postulated a direct ovarian effect of prolactin, reporting that low prolactin levels were essential for progesterone production by preovulatory human granulosa cells cultured in vitro. However, high levels of prolactin decreased progesterone production. The present investigation sought to determine the effect of prolactin on ovulation using the in vitro perfused rabbit ovary preparation. We report that its effects are inhibitory.

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Inhibitory effect of prolactin on ovulation in the in vitro perfused rabbit ovary

Abstract

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