Inhibition of Urinary 17-Ketosteroid Excretion Produced by “Benemid”

Lytt I. Gardner; John F. Crigler; Claude J. Migeon

doi:10.3181/00379727-78-19103

Inhibition of Urinary 17-Ketosteroid Excretion Produced by “Benemid”

Lytt I. Gardner, John F. Crigler, Claude J. Migeon

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

(1) The data presented demonstrate that Benemid in doses of 2 g per day per adult produced approximately 50% diminution in urinary 17-keto-steroids. This diminution was not exaggerated by increasing the dose of Benemid to 4 g per day. (2) Spectrophotometric studies showed that Benemid did not change the androsterone-dehydroisoandrosterone ratio of urinary 17-ketosteroids. (3) Urinary estrogens were diminished in one subject. In another subject this diminution was questionable. (4) Urinary 11-oxycorticosteroids (neutral reducing lipids) did not appear to be affected by Benemid.

Original language	English (US)
Pages (from-to)	460-463
Number of pages	4
Journal	Proceedings of the Society for Experimental Biology and Medicine
Volume	78
Issue number	2
DOIs	https://doi.org/10.3181/00379727-78-19103
State	Published - Nov 1951
Externally published	Yes

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.3181/00379727-78-19103

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title = "Inhibition of Urinary 17-Ketosteroid Excretion Produced by “Benemid”",

abstract = "(1) The data presented demonstrate that Benemid in doses of 2 g per day per adult produced approximately 50% diminution in urinary 17-keto-steroids. This diminution was not exaggerated by increasing the dose of Benemid to 4 g per day. (2) Spectrophotometric studies showed that Benemid did not change the androsterone-dehydroisoandrosterone ratio of urinary 17-ketosteroids. (3) Urinary estrogens were diminished in one subject. In another subject this diminution was questionable. (4) Urinary 11-oxycorticosteroids (neutral reducing lipids) did not appear to be affected by Benemid.",

author = "Gardner, {Lytt I.} and Crigler, {John F.} and Migeon, {Claude J.}",

note = "Funding Information: This study was made possible by grants-in-aid from the American Cancer Society, the U. S. Public Health Service and the M. & R. Dietetic Laboratories.",

year = "1951",

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doi = "10.3181/00379727-78-19103",

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T1 - Inhibition of Urinary 17-Ketosteroid Excretion Produced by “Benemid”

AU - Gardner, Lytt I.

AU - Crigler, John F.

AU - Migeon, Claude J.

N1 - Funding Information: This study was made possible by grants-in-aid from the American Cancer Society, the U. S. Public Health Service and the M. & R. Dietetic Laboratories.

PY - 1951/11

Y1 - 1951/11

N2 - (1) The data presented demonstrate that Benemid in doses of 2 g per day per adult produced approximately 50% diminution in urinary 17-keto-steroids. This diminution was not exaggerated by increasing the dose of Benemid to 4 g per day. (2) Spectrophotometric studies showed that Benemid did not change the androsterone-dehydroisoandrosterone ratio of urinary 17-ketosteroids. (3) Urinary estrogens were diminished in one subject. In another subject this diminution was questionable. (4) Urinary 11-oxycorticosteroids (neutral reducing lipids) did not appear to be affected by Benemid.

AB - (1) The data presented demonstrate that Benemid in doses of 2 g per day per adult produced approximately 50% diminution in urinary 17-keto-steroids. This diminution was not exaggerated by increasing the dose of Benemid to 4 g per day. (2) Spectrophotometric studies showed that Benemid did not change the androsterone-dehydroisoandrosterone ratio of urinary 17-ketosteroids. (3) Urinary estrogens were diminished in one subject. In another subject this diminution was questionable. (4) Urinary 11-oxycorticosteroids (neutral reducing lipids) did not appear to be affected by Benemid.

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Inhibition of Urinary 17-Ketosteroid Excretion Produced by “Benemid”

Abstract

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