TY - JOUR
T1 - Inhibition of the miR-192/215-Rab11-FIP2 axis suppresses human gastric cancer progression article
AU - Zhang, Xiaojing
AU - Peng, Yin
AU - Huang, Yong
AU - Deng, Shiqi
AU - Feng, Xianling
AU - Hou, Gangqiang
AU - Lin, Huijuan
AU - Wang, Jian
AU - Yan, Ruibin
AU - Zhao, Yanqiu
AU - Fan, Xinmin
AU - Meltzer, Stephen J.
AU - Li, Song
AU - Jin, Zhe
N1 - Funding Information:
We are grateful to Drs. Hassan Ashktorab and Duane Smoot for the provision of HFE-145 cells. This research is supported by National Nature Science Foundation of China (81772592) to Z.J.; National Natural Youth Science Foundation of China (81302151) to X.Z.; National Natural Youth Science Foundation of China (31601028) to Y.P.; The Planned Science and Technology Project of Shenzhen (JCYJ20170818142852491), The Planned Science and Technology Project of Shenzhen (JCYJ20140418095735574), and The Key Laboratory Project of Shenzhen (ZDSY20130329101130496) to Z.J.; Nature Science Foundation of Guangdong Province (2017A030313479), The Planned Science and Technology Project of Shenzhen (JCYJ20160422170722474), and Medical Science And Technology Research Foundation of Guangdong Province (A2016112) to X.Z.; Nature Science Foundation of Guangdong Province (2017A030313144) and Startup Fund of Shenzhen University (2018015) to Y.P.; Medical Science And Technology Research Foundation of Guangdong Province (A2017620) to G.H.; NIH grants DK087454, CA146799, CA173390, and an American Cancer Society Clinical Research Professorship to S.J.M. Dr. Meltzer is the Harry B. Myerberg-Thomas R. Hendrix Professor of Gastroenterology.
Publisher Copyright:
© 2018 The Author(s).
PY - 2018/7/1
Y1 - 2018/7/1
N2 - Less than a century ago, gastric cancer (GC) was the most common cancer throughout the world. Despite advances in surgical, chemotherapeutic, and radiotherapeutic treatment, GC remains the number 3 cancer killer worldwide. This fact highlights the need for better diagnostic biomarkers and more effective therapeutic targets. RAB11-FIP2, a member of the Rab11 family of interacting proteins, exhibits potential tumor suppressor function. However, involvement of RAB11-FIP2 in gastric carcinogenesis is yet to be elucidated. In this study, we demonstrated that RAB11-FIP2 was downregulated in GC tissues and constituted a target of the known onco-miRs, miR-192/215. We also showed that functionally, Rab11-FIP2 regulation by miR-192/215 is involved in GC-related biological activities. Finally, RAB11-FIP2 inhibition by miR-192/215 affected the establishment of cell polarity and tight junction formation in GC cells. In summary, this miR-192/215-Rab11-FIP2 axis appears to represent a new molecular mechanism underlying GC progression, while supplying a promising avenue of further research into diagnosis and therapy of GC.
AB - Less than a century ago, gastric cancer (GC) was the most common cancer throughout the world. Despite advances in surgical, chemotherapeutic, and radiotherapeutic treatment, GC remains the number 3 cancer killer worldwide. This fact highlights the need for better diagnostic biomarkers and more effective therapeutic targets. RAB11-FIP2, a member of the Rab11 family of interacting proteins, exhibits potential tumor suppressor function. However, involvement of RAB11-FIP2 in gastric carcinogenesis is yet to be elucidated. In this study, we demonstrated that RAB11-FIP2 was downregulated in GC tissues and constituted a target of the known onco-miRs, miR-192/215. We also showed that functionally, Rab11-FIP2 regulation by miR-192/215 is involved in GC-related biological activities. Finally, RAB11-FIP2 inhibition by miR-192/215 affected the establishment of cell polarity and tight junction formation in GC cells. In summary, this miR-192/215-Rab11-FIP2 axis appears to represent a new molecular mechanism underlying GC progression, while supplying a promising avenue of further research into diagnosis and therapy of GC.
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U2 - 10.1038/s41419-018-0785-5
DO - 10.1038/s41419-018-0785-5
M3 - Article
C2 - 30006518
AN - SCOPUS:85050018210
SN - 2041-4889
VL - 9
JO - Cell Death and Disease
JF - Cell Death and Disease
IS - 7
M1 - 778
ER -