Inhibition of the alloantibody response by CD95 ligand

Hiroshi Arai; Sherri Y. Chan; D. Keith Bishop; Gary J. Nabel

doi:10.1038/nm0897-843

Inhibition of the alloantibody response by CD95 ligand

Hiroshi Arai, Sherri Y. Chan, D. Keith Bishop, Gary J. Nabel

Research output: Contribution to journal › Article › peer-review

76 Scopus citations

Abstract

We investigated the effect of Fas/APO1-ligand (CD95L) gene transfer on allogenic immune responses in vivo. A colon carcinoma cell line from BALB/c mice, CT26, was stably transferred with a vector encoding mouse CD95L and was inoculated into C57BL/6 mice. CD95L expression markedly reduced allogeneic cytotoxic T lymphocyte and helper T lymphocyte activity directed toward CT26. Strikingly, expression of CD95L on these allogeneic tumors completely inhibited the generation of allonatibodies of both IgM and IgG subclasses. Thus, CD95L inhibited alloantibody production and conferred localized immune suppression through this mechanism. These results provide insight into the role of CD95L in regulating the alloantibody response and the generation of local immune responses.

Original language	English (US)
Pages (from-to)	843-848
Number of pages	6
Journal	Nature Medicine
Volume	3
Issue number	8
DOIs	https://doi.org/10.1038/nm0897-843
State	Published - Aug 1997
Externally published	Yes

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology
General Medicine

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title = "Inhibition of the alloantibody response by CD95 ligand",

abstract = "We investigated the effect of Fas/APO1-ligand (CD95L) gene transfer on allogenic immune responses in vivo. A colon carcinoma cell line from BALB/c mice, CT26, was stably transferred with a vector encoding mouse CD95L and was inoculated into C57BL/6 mice. CD95L expression markedly reduced allogeneic cytotoxic T lymphocyte and helper T lymphocyte activity directed toward CT26. Strikingly, expression of CD95L on these allogeneic tumors completely inhibited the generation of allonatibodies of both IgM and IgG subclasses. Thus, CD95L inhibited alloantibody production and conferred localized immune suppression through this mechanism. These results provide insight into the role of CD95L in regulating the alloantibody response and the generation of local immune responses.",

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AU - Arai, Hiroshi

AU - Chan, Sherri Y.

AU - Bishop, D. Keith

AU - Nabel, Gary J.

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AB - We investigated the effect of Fas/APO1-ligand (CD95L) gene transfer on allogenic immune responses in vivo. A colon carcinoma cell line from BALB/c mice, CT26, was stably transferred with a vector encoding mouse CD95L and was inoculated into C57BL/6 mice. CD95L expression markedly reduced allogeneic cytotoxic T lymphocyte and helper T lymphocyte activity directed toward CT26. Strikingly, expression of CD95L on these allogeneic tumors completely inhibited the generation of allonatibodies of both IgM and IgG subclasses. Thus, CD95L inhibited alloantibody production and conferred localized immune suppression through this mechanism. These results provide insight into the role of CD95L in regulating the alloantibody response and the generation of local immune responses.

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Inhibition of the alloantibody response by CD95 ligand

Abstract

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