Inhibition of quorum sensing in Vibrio harveyi by boronic acids

Nanting Ni, Gaurav Choudhary, Hanjing Peng, Minyong Li, Han Ting Chou, Chung Dar Lu, Eric S. Gilbert, Binghe Wang

Research output: Contribution to journalArticlepeer-review

24 Scopus citations


Bacterial quorum sensing refers to the ability of bacteria to control gene expression through the detection of a threshold concentration of certain chemicals called autoinducer(s), which are secreted by self and/or other bacteria. Quorum sensing is implicated in the regulation of pathologically relevant events such as biofilm formation, virulence, conjugation, sporulation, and swarming mobility. Inhibitors of bacterial quorum sensing are valuable research tools and potential antimicrobial agents. In this paper, we describe the discovery of several boronic acid inhibitors of bacterial quorum sensing in Vibrio harveyi with IC50 values in the low to sub-micromolar range in whole cell assays.

Original languageEnglish (US)
Pages (from-to)51-56
Number of pages6
JournalChemical Biology and Drug Design
Issue number1
StatePublished - Jul 2009
Externally publishedYes


  • Autoinducer-1
  • Autoinducer-2
  • Inhibitors
  • Luminescence

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Pharmacology
  • Drug Discovery
  • Organic Chemistry


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