Inhibition of phorbol ester action in lymphocytes by 5,6-epoxy-β-ionone

Philip W. Wertz; Thomas W. Kensler; Gerald C. Mueller

doi:10.1016/0006-291X(78)90408-4

Inhibition of phorbol ester action in lymphocytes by 5,6-epoxy-β-ionone

Philip W. Wertz, Thomas W. Kensler, Gerald C. Mueller

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

The tumor promoting agent, 12-0-tetradecanoylphorbol-13-acetate (TPA) is both a highly active stimulator of phospholipid metabolism and a potent comitogen in bovine lymphocytes. Retinoic acid and the short chain analog, β-ionone, antagonize TPA action, but exhibit broad dose-response curves suggesting a requirement for metabolic activation of these inhibitors. In the present study 5,6-epoxy-β-ionone has been synthesized as a model metabolite and shown to be a more effective inhibitor of TPA action than the parent compound, β-ionone. The data are in accord with the concept that activation of both β-ionone and retinoic acid may proceed by epoxidation.

Original language	English (US)
Pages (from-to)	138-143
Number of pages	6
Journal	Biochemical and Biophysical Research Communications
Volume	83
Issue number	1
DOIs	https://doi.org/10.1016/0006-291X(78)90408-4
State	Published - Jul 14 1978
Externally published	Yes

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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title = "Inhibition of phorbol ester action in lymphocytes by 5,6-epoxy-β-ionone",

abstract = "The tumor promoting agent, 12-0-tetradecanoylphorbol-13-acetate (TPA) is both a highly active stimulator of phospholipid metabolism and a potent comitogen in bovine lymphocytes. Retinoic acid and the short chain analog, β-ionone, antagonize TPA action, but exhibit broad dose-response curves suggesting a requirement for metabolic activation of these inhibitors. In the present study 5,6-epoxy-β-ionone has been synthesized as a model metabolite and shown to be a more effective inhibitor of TPA action than the parent compound, β-ionone. The data are in accord with the concept that activation of both β-ionone and retinoic acid may proceed by epoxidation.",

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T1 - Inhibition of phorbol ester action in lymphocytes by 5,6-epoxy-β-ionone

AU - Wertz, Philip W.

AU - Kensler, Thomas W.

AU - Mueller, Gerald C.

PY - 1978/7/14

Y1 - 1978/7/14

N2 - The tumor promoting agent, 12-0-tetradecanoylphorbol-13-acetate (TPA) is both a highly active stimulator of phospholipid metabolism and a potent comitogen in bovine lymphocytes. Retinoic acid and the short chain analog, β-ionone, antagonize TPA action, but exhibit broad dose-response curves suggesting a requirement for metabolic activation of these inhibitors. In the present study 5,6-epoxy-β-ionone has been synthesized as a model metabolite and shown to be a more effective inhibitor of TPA action than the parent compound, β-ionone. The data are in accord with the concept that activation of both β-ionone and retinoic acid may proceed by epoxidation.

AB - The tumor promoting agent, 12-0-tetradecanoylphorbol-13-acetate (TPA) is both a highly active stimulator of phospholipid metabolism and a potent comitogen in bovine lymphocytes. Retinoic acid and the short chain analog, β-ionone, antagonize TPA action, but exhibit broad dose-response curves suggesting a requirement for metabolic activation of these inhibitors. In the present study 5,6-epoxy-β-ionone has been synthesized as a model metabolite and shown to be a more effective inhibitor of TPA action than the parent compound, β-ionone. The data are in accord with the concept that activation of both β-ionone and retinoic acid may proceed by epoxidation.

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Inhibition of phorbol ester action in lymphocytes by 5,6-epoxy-β-ionone

Abstract

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