Inhibition of neutral sphingomyelinase 2 impairs HIV-1 envelope formation and substantially delays or eliminates viral rebound

Keyphrases

• HIV-1 Envelope 100%
• Neutral Sphingomyelinase 100%
• Viral Rebound 100%
• Human Immunodeficiency Virus Type 1 (HIV-1) 85%
• Sphingomyelin 28%
• HIV-1 Gag 28%
• Plasma Parameters 14%
• Therapeutic Target 14%
• Culture Results 14%
• Plasma Membrane 14%
• Infected Cells 14%
• Ceramide 14%
• Hydrolysis 14%
• Selective Inhibitor 14%
• Phenyl 14%
• Potent Inhibitor 14%
• Viral Envelope 14%
• Virion 14%
• Tissue Culture 14%
• Non-infectious 14%
• Lipid Composition 14%
• HIV-1 Replication 14%
• Hydrolases 14%
• Viral Assembly 14%
• Carbamate 14%
• Pyridazin 14%
• (R)-1 14%
• Humanized Mouse Model 14%
• Viral Budding 14%
• In Vivo Culture 14%
• Viral Maturation 14%
• Conical Core 14%
• Linear Reduction 14%

Biochemistry, Genetics and Molecular Biology

• Human Immunodeficiency Virus 1 100%
• Rebound 100%
• Acid Sphingomyelinase 100%
• Sphingomyelin Phosphodiesterase 100%
• Sphingomyelin 20%
• Blood Level 10%
• Cell Membrane 10%
• Mouse Model 10%
• Maturation 10%
• Enzymatic Hydrolysis 10%
• Hydrolase 10%
• Tissue Culture 10%
• Ceramide 10%
• Virion 10%
• Virus Assembly 10%
• Lipid Composition 10%
• Virus Release 10%
• Virus Envelope 10%
• in Vivo Culture 10%

Immunology and Microbiology

• Human Immunodeficiency Virus 1 100%
• Rebound 100%
• Mouse Model 10%
• Cell Membrane 10%
• Viral Envelope 10%
• Maturation 10%
• Blood Plasma 10%
• Blood Level 10%
• Virion 10%
• Lipid Composition 10%
• Virus Assembly 10%
• Tissue Culture 10%
• Virus Release 10%
• Humanized Mouse 10%
• in Vivo Culture 10%