Inhibition of idiotype - Anti-idiotype interaction for detection of a parasite antigen: A new immunoassay

Pedro Potocnjak; Fidel Zavala; Ruth Nussenzweig; Victor Nussenzweig

doi:10.1126/science.6122269

Inhibition of idiotype - Anti-idiotype interaction for detection of a parasite antigen: A new immunoassay

Pedro Potocnjak, Fidel Zavala, Ruth Nussenzweig, Victor Nussenzweig

Research output: Contribution to journal › Article › peer-review

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Abstract

Described in this report is an immunoradiometric assay of general applicability that is based on a new principle: the inhibition of the interaction between monoclonal antibodies by an antigen. The advantages of this assay are that it measures concentrations of single epitopes, purified antigen is not required, and the reagents can be obtained in unlimited amounts and are homogeneous. Its features are particularly attractive when the antigen has not been purified and is a minor component of a complex mixture of molecules.

Original language	English (US)
Pages (from-to)	1637-1639
Number of pages	3
Journal	Science
Volume	216
Issue number	4540
DOIs	https://doi.org/10.1126/science.6122269
State	Published - 1982
Externally published	Yes

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abstract = "Described in this report is an immunoradiometric assay of general applicability that is based on a new principle: the inhibition of the interaction between monoclonal antibodies by an antigen. The advantages of this assay are that it measures concentrations of single epitopes, purified antigen is not required, and the reagents can be obtained in unlimited amounts and are homogeneous. Its features are particularly attractive when the antigen has not been purified and is a minor component of a complex mixture of molecules.",

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AU - Nussenzweig, Victor

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Inhibition of idiotype - Anti-idiotype interaction for detection of a parasite antigen: A new immunoassay

Abstract

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