Inherited Retinal Degenerations and Non-Neovascular Age-Related Macular Degeneration: Progress and Unmet Needs

Jacque L. Duncan; Angela Bowman; Amy Laster; Claire Gelfman; David G. Birch; Shannon E. Boye; Stephen P. Daiger; Lucian Del Priore; Donald J. Zack; James T. Handa

doi:10.1167/tvst.13.12.28

Inherited Retinal Degenerations and Non-Neovascular Age-Related Macular Degeneration: Progress and Unmet Needs

Jacque L. Duncan, Angela Bowman, Amy Laster, Claire Gelfman, David G. Birch, Shannon E. Boye, Stephen P. Daiger, Lucian Del Priore, Donald J. Zack, James T. Handa

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Inherited retinal degeneration (IRD) disease and age-related macular degeneration (AMD) are leading causes of irreversible vision loss and blindness. Although significant progress has advanced the field in the past 5 years, significant challenges remain. The current article reviews the accomplishments and research advances that have fueled the development of treatments for patients with IRD and AMD, including the first approved gene-augmentation treatment for RPE65-related retinal degeneration and complement inhibition therapies to slow progression of geographic atrophy (GA) in AMD.Thearticleoutlinesopportunitiestoaddressgapsandunmetneedsthatshould lead to additional progress toward the development of treatments for patients with IRDs and non-neovascular AMD in the future.

Original language	English (US)
Article number	28
Journal	Translational Vision Science and Technology
Volume	13
Issue number	12
DOIs	https://doi.org/10.1167/tvst.13.12.28
State	Published - Dec 1 2024

Keywords

age-related macular degeneration (AMD)
gap analysis
inherited retinal degeneration (IRD) diseases

ASJC Scopus subject areas

Biomedical Engineering
Ophthalmology

Access to Document

10.1167/tvst.13.12.28

Cite this

@article{f412061aaa6e491586904616a5f2c8bb,

title = "Inherited Retinal Degenerations and Non-Neovascular Age-Related Macular Degeneration: Progress and Unmet Needs",

abstract = "Inherited retinal degeneration (IRD) disease and age-related macular degeneration (AMD) are leading causes of irreversible vision loss and blindness. Although significant progress has advanced the field in the past 5 years, significant challenges remain. The current article reviews the accomplishments and research advances that have fueled the development of treatments for patients with IRD and AMD, including the first approved gene-augmentation treatment for RPE65-related retinal degeneration and complement inhibition therapies to slow progression of geographic atrophy (GA) in AMD.Thearticleoutlinesopportunitiestoaddressgapsandunmetneedsthatshould lead to additional progress toward the development of treatments for patients with IRDs and non-neovascular AMD in the future.",

keywords = "age-related macular degeneration (AMD), gap analysis, inherited retinal degeneration (IRD) diseases",

author = "Duncan, {Jacque L.} and Angela Bowman and Amy Laster and Claire Gelfman and Birch, {David G.} and Boye, {Shannon E.} and Daiger, {Stephen P.} and {Del Priore}, Lucian and Zack, {Donald J.} and Handa, {James T.}",

note = "Publisher Copyright: {\textcopyright} 2024 The Authors.",

year = "2024",

month = dec,

day = "1",

doi = "10.1167/tvst.13.12.28",

language = "English (US)",

volume = "13",

journal = "Translational Vision Science and Technology",

issn = "2164-2591",

publisher = "Association for Research in Vision and Ophthalmology Inc.",

number = "12",

}

TY - JOUR

T1 - Inherited Retinal Degenerations and Non-Neovascular Age-Related Macular Degeneration

T2 - Progress and Unmet Needs

AU - Duncan, Jacque L.

AU - Bowman, Angela

AU - Laster, Amy

AU - Gelfman, Claire

AU - Birch, David G.

AU - Boye, Shannon E.

AU - Daiger, Stephen P.

AU - Del Priore, Lucian

AU - Zack, Donald J.

AU - Handa, James T.

PY - 2024/12/1

Y1 - 2024/12/1

N2 - Inherited retinal degeneration (IRD) disease and age-related macular degeneration (AMD) are leading causes of irreversible vision loss and blindness. Although significant progress has advanced the field in the past 5 years, significant challenges remain. The current article reviews the accomplishments and research advances that have fueled the development of treatments for patients with IRD and AMD, including the first approved gene-augmentation treatment for RPE65-related retinal degeneration and complement inhibition therapies to slow progression of geographic atrophy (GA) in AMD.Thearticleoutlinesopportunitiestoaddressgapsandunmetneedsthatshould lead to additional progress toward the development of treatments for patients with IRDs and non-neovascular AMD in the future.

AB - Inherited retinal degeneration (IRD) disease and age-related macular degeneration (AMD) are leading causes of irreversible vision loss and blindness. Although significant progress has advanced the field in the past 5 years, significant challenges remain. The current article reviews the accomplishments and research advances that have fueled the development of treatments for patients with IRD and AMD, including the first approved gene-augmentation treatment for RPE65-related retinal degeneration and complement inhibition therapies to slow progression of geographic atrophy (GA) in AMD.Thearticleoutlinesopportunitiestoaddressgapsandunmetneedsthatshould lead to additional progress toward the development of treatments for patients with IRDs and non-neovascular AMD in the future.

KW - age-related macular degeneration (AMD)

KW - gap analysis

KW - inherited retinal degeneration (IRD) diseases

UR - http://www.scopus.com/inward/record.url?scp=85212895790&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85212895790&partnerID=8YFLogxK

U2 - 10.1167/tvst.13.12.28

DO - 10.1167/tvst.13.12.28

M3 - Article

C2 - 39688851

AN - SCOPUS:85212895790

SN - 2164-2591

VL - 13

JO - Translational Vision Science and Technology

JF - Translational Vision Science and Technology

IS - 12

M1 - 28

ER -

Inherited Retinal Degenerations and Non-Neovascular Age-Related Macular Degeneration: Progress and Unmet Needs

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this