Abstract
The fluorescence anisotropy of 1,6-diphenyl-1,3,5-hexatriene in labeled platelet membranes, an index of membrane fluidity, is a stable, familial trait that is associated with a clinically distinct subtype of Alzheimer disease. Complex segregation analysis of this continuous variable was performed on 95 members of 14 pedigrees identified through probands who had autopsy-confirmed or clinically diagnosed Alzheimer disease. The results suggest that platelet membrane fluidity is controlled by a single genetic locus, PMF, with two alleles that have additive effects. The PMF locus appears to explain approximately 80% of the total variation in platelet membrane fluidity within the families of patients with Alzheimer disease.
Original language | English (US) |
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Pages (from-to) | 799-805 |
Number of pages | 7 |
Journal | American journal of human genetics |
Volume | 44 |
Issue number | 6 |
State | Published - 1989 |
Externally published | Yes |
ASJC Scopus subject areas
- Genetics
- Genetics(clinical)