Abstract
The fluorescence anisotropy of 1,6-diphenyl-1,3,5-hexatriene in labeled platelet membranes, an index of membrane fluidity, is a stable, familial trait that is associated with a clinically distinct subtype of Alzheimer disease. Complex segregation analysis of this continuous variable was performed on 95 members of 14 pedigrees identified through probands who had autopsy-confirmed or clinically diagnosed Alzheimer disease. The results suggest that platelet membrane fluidity is controlled by a single genetic locus, PMF, with two alleles that have additive effects. The PMF locus appears to explain approximately 80% of the total variation in platelet membrane fluidity within the families of patients with Alzheimer disease.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 799-805 |
| Number of pages | 7 |
| Journal | American journal of human genetics |
| Volume | 44 |
| Issue number | 6 |
| State | Published - 1989 |
| Externally published | Yes |
ASJC Scopus subject areas
- Genetics
- Genetics(clinical)