Inheritance pattern of platelet membrane fluidity in Alzheimer disease

A. Chakravarti, S. A. Slaugenhaupt, G. S. Zubenko

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


The fluorescence anisotropy of 1,6-diphenyl-1,3,5-hexatriene in labeled platelet membranes, an index of membrane fluidity, is a stable, familial trait that is associated with a clinically distinct subtype of Alzheimer disease. Complex segregation analysis of this continuous variable was performed on 95 members of 14 pedigrees identified through probands who had autopsy-confirmed or clinically diagnosed Alzheimer disease. The results suggest that platelet membrane fluidity is controlled by a single genetic locus, PMF, with two alleles that have additive effects. The PMF locus appears to explain approximately 80% of the total variation in platelet membrane fluidity within the families of patients with Alzheimer disease.

Original languageEnglish (US)
Pages (from-to)799-805
Number of pages7
JournalAmerican journal of human genetics
Issue number6
StatePublished - 1989
Externally publishedYes

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)


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