Inhaled prostacyclin in combination with high-frequency percussive ventilation

Patrick F. Allan, Cindy A. Codispoti, Shannon G. Womble, Michael L. Overton, Sandra M. Wanek, John H. Sherner, Raymond Fang, Steven V. Silvey

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


We present a case of severe acute respiratory distress syndrome pursuant to inhalation of a compressed gas computer keyboard cleaner. Despite the use of multimodal therapy to include empiric antibiotics, intravenous paralytics, intravenous concentrated albumin, high-dose corticosteroids as well as sustained high mean airway pressure mechanical ventilation by airway pressure release and high-frequency percussive ventilation (HFPV) modes, the patient demonstrated an unchanging arterial oxygen tension/fraction of inspired oxygen ratio of only 57 mm Hg. A trial of nebulized prostacyclin was initiated during HFPV leading to a significant improvement in arterial oxygen tension/fraction of inspired oxygen to 147 mm Hg. The improved oxygen tension allowed for a reduction in mean airway pressure and oxygen concentration as well the safe aeromedical evacuation of the patient from the combat theater. Further, prospective studies are required to validate the magnitude of response to inhaled prostacyclin during HFPV.

Original languageEnglish (US)
Pages (from-to)347-352
Number of pages6
JournalJournal of Burn Care and Research
Issue number2
StatePublished - Mar 2010
Externally publishedYes

ASJC Scopus subject areas

  • Surgery
  • Emergency Medicine
  • Rehabilitation


Dive into the research topics of 'Inhaled prostacyclin in combination with high-frequency percussive ventilation'. Together they form a unique fingerprint.

Cite this