Abstract
Horizontal transmission of rotavirus vaccine virus may contribute to indirect effects of rotavirus vaccine, but data are lacking from low-income countries. Serial stool samples were obtained from Malawian infants who received 2 doses of monovalent human rotavirus vaccine (RV1) (days 4, 6, 8, and 10 after vaccination) and from their household contacts (8-10 days after vaccine). RV1 vaccine virus in stool was detected using semi-quantitative real-time reverse-transcription polymerase chain reaction. RV1 fecal shedding was detected in 41 of 60 vaccinated infants (68%) and in 2 of 147 household contacts (1.4%). Horizontal transmission of vaccine virus within households is unlikely to make a major contribution to RV1 indirect effects in Malawi.
Original language | English (US) |
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Pages (from-to) | 1730-1734 |
Number of pages | 5 |
Journal | Journal of Infectious Diseases |
Volume | 219 |
Issue number | 11 |
DOIs | |
State | Published - Jun 1 2019 |
Keywords
- Indirect effects
- Malawi
- Rotavirus
- Transmission
- Vaccine
ASJC Scopus subject areas
- General Medicine