Influence of renal insufficiency on levels of serum ribonuclease in patients with multiple myeloma

Timothy P. Karpetsky, Richard L. Humphrey, Carl C. Levy

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33 Scopus citations


Serum RNase levels were measured in 34 patients with multiple myeloma and compared with 51 normal controls and 28 non-myeloma patients on chronic hemodialysis. Nineteen of the myeloma patients with creatinine clearance (Ccr) greater than 50 ml/minute had mean serum RNase levels that were statistically indistinguishable from those of the normal controls. The 15 myeloma patients with CCr less than 50 ml/minute had mean RNase levels much higher than normal controls or myeloma patients with normal renal function. Patients without myeloma but on hemodialysis for chronic renal failure of varied etiologies had markedly elevated serum RNase levels. A strong correlation between RNase levels and renal insufficiency, as measured by CCr, has thus been demonstrated. In addition, case histories of 5 representative myeloma patients were analyzed in greater detail; they illustrated the rise and fall of RNase levels as a function of the status of their renal insufficiency, regardless of the extent of the underlying myeloma. We concluded that the serum RNase level was an indicator of renal function, and was not a biomarker either for the presence or extent of the plasma cell tumor.

Original languageEnglish (US)
Pages (from-to)875-880
Number of pages6
JournalJournal of the National Cancer Institute
Issue number4
StatePublished - Apr 1977
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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