Influence of Purkinje-muscle coupling on EAD development: A simulation study

M. Monserrat, J. Saiz, J. M. Ferrero, V. Torres, J. M. Ferrero, N. V. Thakor

Research output: Contribution to journalConference articlepeer-review

1 Scopus citations


Early afterdepolarizations (EADs) are irregularities that occur during the repolarization phase of the action potential (AP) interrupting or delaying normal repolarization. In this work, computer simulations have been used to study the influence of Purkinje-muscle coupling on EADs generated in Purkinje cells. The electrical behaviour of the ventricular (v) and Purkinje (P) cells have been simulated using the Luo-Rudy phase II model and the DiFrancesco-Noble equations, respectively. EADs were induced in the P cells by enhancing the Ca2+ current through the L-type channels and partially blocking the delayed rectifying K+ current. Our results suggest that the P-V connection reduces the likelihood of appearance of EADs in Purkinje fibers (PFs). Moreover, when FADs occur in P cells, there is a range of coupling values that allows their propagation as APs to the V cells.

Original languageEnglish (US)
Pages (from-to)513-516
Number of pages4
JournalComputers in cardiology
StatePublished - 1997
Externally publishedYes
EventProceedings of the 1997 24th Annual Meeting on Computers in Cardiology - Lund, Sweden
Duration: Sep 7 1997Sep 10 1997

ASJC Scopus subject areas

  • Computer Science Applications
  • Cardiology and Cardiovascular Medicine


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