Influence of prior pneumococcal and influenza vaccination on outcomes of older adults with community-acquired pneumonia

Adriana Manzur, Conchita Izquierdo, Laura Ruiz, Dolores Sousa, Jose María Bayas, Jose Miguel Celorrio, Wenceslao Varona, Manel Nebot, Lluis Salleras, Angela Domínguez, Jordi Carratalà

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


OBJECTIVES: To determine whether prior pneumococcal and seasonal influenza vaccination improves outcomes in older adults hospitalized for community-acquired pneumonia (CAP). DESIGN: Prospective, observational, multicenter study. SETTING: Five public hospitals providing universal free care to the whole population in three Spanish regions. PARTICIPANTS: Individuals aged 65 and older admitted to the hospital with CAP through the emergency department. MEASUREMENTS: Pneumococcal and influenza vaccination status. The primary study outcomes were intensive care unit (ICU) admission, length of hospital stay (LOS), and overall case-fatality rate. Outcome variables of individuals vaccinated with both vaccines were compared with outcomes of those who were unvaccinated. RESULTS: Two hundred thirty-eight individuals had received 23-valent pneumococcal polysaccharide vaccine and seasonal influenza vaccination and were compared with 195 unvaccinated individuals. No differences were found with respect to combined antibiotic therapy between groups (38.0% vs 39.7%; P=.80). Similar percentages of vaccinated and unvaccinated individuals required ICU admission (7.2% vs 8.2%; P=.69). Mean LOS was significantly shorter in vaccinated individuals (9.9 vs 12.4 days; P =.04). Overall case-fatality rates were similar in both groups (5.9% vs 5.1%; P=.73). After adjustment, LOS, risk of ICU admission, and overall case-fatality rate were not associated with prior pneumococcal and seasonal influenza vaccination. CONCLUSION: The clinical outcomes ofvaccinated older adults hospitalized with CAP were not better than those observed in unvaccinated individuals.

Original languageEnglish (US)
Pages (from-to)1711-1716
Number of pages6
JournalJournal of the American Geriatrics Society
Issue number9
StatePublished - Sep 2011
Externally publishedYes


  • Community-acquired pneumonia
  • Influenza vaccination
  • Pneumococcal vaccination

ASJC Scopus subject areas

  • Geriatrics and Gerontology


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