Influence of hypoxic-preconditioning on autonomic regulation following global ischemic brain injury in rats

Wenqing Wu, Xiaoli Guo, Dineng Jiang, Junfeng Sun, Yihong Qiu, Yisheng Zhu, Nitish V. Thakor, Shanbao Tong

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Experimental and clinical studies have shown that autonomic imbalance is associated with morbidity and mortality due to global ischemic brain injury following cardiac arrest (CA). Although hypoxic-preconditioning (HP) has shown promising neuro-protection in the subsequent ischemic brain injury, the underlying mechanisms and its influence on autonomic regulation have not yet well-understood. In this study, we utilized baroreflex sensitivity (BRS) to investigate the protective effect of HP on autonomic regulation. We investigated changes in heart rate, arterial blood pressure (BP), and BRS within 4. h after CA in rats. The relationship between BRS and neurodeficit score (NDS) was analyzed. Although no significant differences were found in heart rate and BP before and after CA between the control and the preconditioned groups, both BRS and NDS of preconditioned rats were clearly higher than that of the control rats during recovery after CA. Furthermore, BRS in the first 4. h after CA highly correlated with NDS 24. h after CA. These results imply that treatment with HP improves autonomic regulation and protects the brain from ischemic injury. The correlation between BRS and NDS also suggests that BRS can be a prognostic criterion for the level of brain injury after CA.

Original languageEnglish (US)
Pages (from-to)191-195
Number of pages5
JournalNeuroscience Letters
Issue number3
StatePublished - Aug 2010


  • Autonomic nervous system
  • Baroreflex sensitivity
  • Cardiac arrest
  • Hypoxic-preconditioning

ASJC Scopus subject areas

  • General Neuroscience


Dive into the research topics of 'Influence of hypoxic-preconditioning on autonomic regulation following global ischemic brain injury in rats'. Together they form a unique fingerprint.

Cite this