Influence of endogenous reproductive hormones on F2-isoprostane levels in premenopausal women

Enrique F. Schisterman, Audrey J. Gaskins, Sunni L. Mumford, Richard W. Browne, Edwina Yeung, Maurizio Trevisan, Mary Hediger, Cuilin Zhang, Neil J. Perkins, Kathleen Hovey, Jean Wactawski-Wende

Research output: Contribution to journalArticlepeer-review

39 Scopus citations


Endogenous reproductive hormones and oxidative stress have been independently linked to risk of chronic disease but mostly in postmenopausal women. The interplay between endogenous reproductive hormones and oxidative stress among premenopausal women, however, has yet to be clearly elucidated. The objective of this study was to investigate the association between endogenous reproductive hormones and F2-isoprostanes in the BioCycle Study. Women aged 18-44 years from western New York State were followed prospectively for up to 2 menstrual cycles (n = 259) during 2005-2007. Estradiol, progesterone, luteinizing hormone, follicle-stimulating hormone, sex hormone-binding globulin, F2-isoprostanes, and thiobarbituric acid-reactive substances were measured up to 8 times per cycle at clinic visits timed by using fertility monitors. F 2-Isoprostane levels had an independent positive association with estradiol (β = 0.02, 95% confidence interval: 0.01, 0.03) and inverse associations with sex hormone-binding globulin and follicle-stimulating hormone (β =-0.04, 95% confidence interval:-0.07,-0.003; β =-0.02, 95% confidence interval:-0.03,-0.002, respectively) after adjustment for age, race, age at menarche, γ-tocopherol, beta-carotene, total cholesterol, and homocysteine by inverse probability weighting. Thiobarbituric acid-reactive substances, a less specific marker of oxidative stress, had similar associations. If F2-isoprostanes are specific markers of oxidative stress, these results call into question the commonly held hypothesis that endogenous estradiol reduces oxidative stress.

Original languageEnglish (US)
Pages (from-to)430-439
Number of pages10
JournalAmerican Journal of Epidemiology
Issue number4
StatePublished - Aug 15 2010
Externally publishedYes


  • hormones
  • menstrual cycle
  • oxidative stress
  • women

ASJC Scopus subject areas

  • Epidemiology
  • General Medicine


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