Inflammatory myofibroblastic tumor of the placenta: A report of a novel lesion in 2 patients

Natalie Banet, Yi Ning, Elizabeth A. Montgomery

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Inflammatory myofibroblastic tumor has been described in a wide variety of anatomic sites, although in the gynecologic tract, it has mostly been documented in the uterus, and has never been described in the placenta. Two patients presented with wellcircumscribed placental masses that showed classic histologic features of inflammatory myofibroblastic tumor including a proliferation of myofibroblastic cells, a mixed inflammatory infiltrate, and a myxoid background. One case was positive by immunohistochemistry for anaplastic lymphoma kinase (ALK-1), whereas the other was negative by immunohistochemistry and fluorescent in situ hybridization. Inflammatory myofibroblastic tumors should be differentiated from other more aggressive uterine tumors that may involve the placenta by direct extension/metastasis because they can be managed conservatively, and in these 2 cases, did not seem to affect the course of the patient's pregnancies.

Original languageEnglish (US)
Pages (from-to)419-423
Number of pages5
JournalInternational Journal of Gynecological Pathology
Issue number5
StatePublished - Jan 1 2015


  • ALK-1
  • Inflammatory myofibroblastic tumor
  • Placenta

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Obstetrics and Gynecology


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