Inflammatory Markers and Risk for Cognitive Decline in Chronic Kidney Disease: The CRIC Study

Manjula Kurella Tamura, Karman Tam, Eric Vittinghoff, Dominic Raj, Stephen M. Sozio, Sylvia E. Rosas, Gail Makos, Claudia Lora, Jiang He, Alan S. Go, Chi yuan Hsu, Kristine Yaffe, Lawrence J. Appel, Harold I. Feldman, Alan S. Go, John W. Kusek, James P. Lash, Akinlolu Ojo, Mahboob Rahman, Raymond R. Townsend

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


Introduction Chronic kidney disease (CKD) is associated with an increased risk of cognitive decline, but the mechanisms remain poorly defined. We sought to determine the relation between serum inflammatory markers and risk of cognitive decline among adults with CKD. Methods We studied 757 adults aged ≥55 years with CKD participating in the Chronic Renal Insufficiency Cohort Cognitive study. We measured interleukin (IL)−1β, IL-1 receptor antagonist, IL-6, tumor necrosis factor (TNF)−α, high-sensitivity C-reactive protein (hs-CRP), and fibrinogen in baseline plasma samples. We assessed cognitive function at regular intervals in 4 domains and defined incident impairment as a follow-up score more than 1 SD poorer than the group mean. Results The mean age of the sample was 64.3 ± 5.6 years, and the mean follow-up was 6.2 ± 2.5 years. At baseline, higher levels of each inflammatory marker were associated with poorer age-adjusted performance. In analyses adjusted for baseline cognition, demographics, comorbid conditions, and kidney function, participants in the highest tertile of hs-CRP, the highest tertile of fibrinogen, and the highest tertile of IL-1β had an increased risk of impairment in attention compared to participants in the lowest tertile of each marker. Participants in the highest versus lowest tertile of TNF-α had a lower adjusted risk of impairment in executive function. There was no association between other inflammatory markers and change in cognitive function. Discussion Among adults with CKD, higher levels of hs-CRP, fibrinogen, and IL-1β were associated with a higher risk of impairment in attention. Higher levels of TNF-α were associated with a lower risk of impaired executive function.

Original languageEnglish (US)
Pages (from-to)192-200
Number of pages9
JournalKidney International Reports
Issue number2
StatePublished - 2017


  • aging
  • chronic kidney disease
  • cognitive decline
  • dementia
  • epidemiology
  • inflammation

ASJC Scopus subject areas

  • Nephrology


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