Inflammatory gene variants and the risk of biliary tract cancers and stones: A population-based study in China

Felipe A. Castro; Jill Koshiol; Ann W. Hsing; Yu Tang Gao; Asif Rashid; Lisa W. Chu; Ming Chang Shen; Bing Shen Wang; Tian Qua Han; Bai He Zhang; Shelley Niwa; Kai Yu; Hong Zhang; Stephen Chanock; Gabriella Andreotti

doi:10.1186/1471-2407-12-468

Inflammatory gene variants and the risk of biliary tract cancers and stones: A population-based study in China

Felipe A. Castro, Jill Koshiol, Ann W. Hsing, Yu Tang Gao, Asif Rashid, Lisa W. Chu, Ming Chang Shen, Bing Shen Wang, Tian Qua Han, Bai He Zhang, Shelley Niwa, Kai Yu, Hong Zhang, Stephen Chanock, Gabriella Andreotti

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16 Scopus citations

Abstract

Background: Genetic variants in inflammation-related genes have been associated with biliary stones and biliary tract cancers in previous studies.Methods: To follow-up on these findings, we examined 35 single nucleotide polymorphism (SNPs) in 5 genes related to inflammation (IL8, NFKBIL, RNASEL, TNF, and VEGFA) in 456 participants with incident biliary tract cancer cases (262 gallbladder, 141 extrahepatic bile duct, 53 ampulla of Vater), 982 participants with biliary stones, and 860 healthy controls in a population-based case-control study in Shanghai, China.Results: Suggestive associations were observed for SNPs in VEGFA with biliary stones, IL8 with gallbladder and ampulla of Vater cancers, and RNASEL with ampulla of Vater cancer (false discovery rate≤0.2).Conclusion: These findings provide additional support for the role of inflammation in biliary stones and biliary tract cancer risk and need further validation.

Original language	English (US)
Article number	468
Journal	BMC cancer
Volume	12
DOIs	https://doi.org/10.1186/1471-2407-12-468
State	Published - Oct 11 2012
Externally published	Yes

Keywords

Biliary stones
Biliary tract cancer
Genetic susceptibility
Inflammation

ASJC Scopus subject areas

Oncology
Genetics
Cancer Research

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10.1186/1471-2407-12-468

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Castro, F. A., Koshiol, J., Hsing, A. W., Gao, Y. T., Rashid, A., Chu, L. W., Shen, M. C., Wang, B. S., Han, T. Q., Zhang, B. H., Niwa, S., Yu, K., Zhang, H., Chanock, S., & Andreotti, G. (2012). Inflammatory gene variants and the risk of biliary tract cancers and stones: A population-based study in China. BMC cancer, 12, Article 468. https://doi.org/10.1186/1471-2407-12-468

@article{99d12852f8a846649cec0c5ae38c91f8,

title = "Inflammatory gene variants and the risk of biliary tract cancers and stones: A population-based study in China",

abstract = "Background: Genetic variants in inflammation-related genes have been associated with biliary stones and biliary tract cancers in previous studies.Methods: To follow-up on these findings, we examined 35 single nucleotide polymorphism (SNPs) in 5 genes related to inflammation (IL8, NFKBIL, RNASEL, TNF, and VEGFA) in 456 participants with incident biliary tract cancer cases (262 gallbladder, 141 extrahepatic bile duct, 53 ampulla of Vater), 982 participants with biliary stones, and 860 healthy controls in a population-based case-control study in Shanghai, China.Results: Suggestive associations were observed for SNPs in VEGFA with biliary stones, IL8 with gallbladder and ampulla of Vater cancers, and RNASEL with ampulla of Vater cancer (false discovery rate≤0.2).Conclusion: These findings provide additional support for the role of inflammation in biliary stones and biliary tract cancer risk and need further validation.",

keywords = "Biliary stones, Biliary tract cancer, Genetic susceptibility, Inflammation",

author = "Castro, {Felipe A.} and Jill Koshiol and Hsing, {Ann W.} and Gao, {Yu Tang} and Asif Rashid and Chu, {Lisa W.} and Shen, {Ming Chang} and Wang, {Bing Shen} and Han, {Tian Qua} and Zhang, {Bai He} and Shelley Niwa and Kai Yu and Hong Zhang and Stephen Chanock and Gabriella Andreotti",

note = "Funding Information: We thank the collaborating surgeons and pathologists in Shanghai for assistance in patient recruitment and pathology review; Chia–Rong Cheng, Lu Sun, and Kai Wu of the Shanghai Cancer Institute for coordinating data and specimen collection; and Shelley Niwa and Ann Truelove of Westat for support with study and data management. The study was funded by the Intramural Research Program of the National Institute of Health, National Cancer Institute, Division of Cancer Epidemiology and Genetics, USA.",

year = "2012",

month = oct,

day = "11",

doi = "10.1186/1471-2407-12-468",

language = "English (US)",

volume = "12",

journal = "BMC cancer",

issn = "1471-2407",

publisher = "BioMed Central",

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TY - JOUR

T1 - Inflammatory gene variants and the risk of biliary tract cancers and stones

T2 - A population-based study in China

AU - Castro, Felipe A.

AU - Koshiol, Jill

AU - Hsing, Ann W.

AU - Gao, Yu Tang

AU - Rashid, Asif

AU - Chu, Lisa W.

AU - Shen, Ming Chang

AU - Wang, Bing Shen

AU - Han, Tian Qua

AU - Zhang, Bai He

AU - Niwa, Shelley

AU - Yu, Kai

AU - Zhang, Hong

AU - Chanock, Stephen

AU - Andreotti, Gabriella

N1 - Funding Information: We thank the collaborating surgeons and pathologists in Shanghai for assistance in patient recruitment and pathology review; Chia–Rong Cheng, Lu Sun, and Kai Wu of the Shanghai Cancer Institute for coordinating data and specimen collection; and Shelley Niwa and Ann Truelove of Westat for support with study and data management. The study was funded by the Intramural Research Program of the National Institute of Health, National Cancer Institute, Division of Cancer Epidemiology and Genetics, USA.

PY - 2012/10/11

Y1 - 2012/10/11

N2 - Background: Genetic variants in inflammation-related genes have been associated with biliary stones and biliary tract cancers in previous studies.Methods: To follow-up on these findings, we examined 35 single nucleotide polymorphism (SNPs) in 5 genes related to inflammation (IL8, NFKBIL, RNASEL, TNF, and VEGFA) in 456 participants with incident biliary tract cancer cases (262 gallbladder, 141 extrahepatic bile duct, 53 ampulla of Vater), 982 participants with biliary stones, and 860 healthy controls in a population-based case-control study in Shanghai, China.Results: Suggestive associations were observed for SNPs in VEGFA with biliary stones, IL8 with gallbladder and ampulla of Vater cancers, and RNASEL with ampulla of Vater cancer (false discovery rate≤0.2).Conclusion: These findings provide additional support for the role of inflammation in biliary stones and biliary tract cancer risk and need further validation.

AB - Background: Genetic variants in inflammation-related genes have been associated with biliary stones and biliary tract cancers in previous studies.Methods: To follow-up on these findings, we examined 35 single nucleotide polymorphism (SNPs) in 5 genes related to inflammation (IL8, NFKBIL, RNASEL, TNF, and VEGFA) in 456 participants with incident biliary tract cancer cases (262 gallbladder, 141 extrahepatic bile duct, 53 ampulla of Vater), 982 participants with biliary stones, and 860 healthy controls in a population-based case-control study in Shanghai, China.Results: Suggestive associations were observed for SNPs in VEGFA with biliary stones, IL8 with gallbladder and ampulla of Vater cancers, and RNASEL with ampulla of Vater cancer (false discovery rate≤0.2).Conclusion: These findings provide additional support for the role of inflammation in biliary stones and biliary tract cancer risk and need further validation.

KW - Biliary stones

KW - Biliary tract cancer

KW - Genetic susceptibility

KW - Inflammation

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SN - 1471-2407

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JO - BMC cancer

JF - BMC cancer

M1 - 468

ER -

Inflammatory gene variants and the risk of biliary tract cancers and stones: A population-based study in China

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