TY - JOUR
T1 - Inflammatory biomarkers and risk of breast cancer among young women in Latin America
T2 - a case-control study
AU - PRECAMA team
AU - Fontvieille, Emma
AU - His, Mathilde
AU - Biessy, Carine
AU - Navionis, Anne Sophie
AU - Torres-Mejía, Gabriela
AU - Ángeles-Llerenas, Angélica
AU - Alvarado-Cabrero, Isabel
AU - Sánchez, Gloria Inés
AU - Navarro, Edgar
AU - Cortes, Yorlany Rodas
AU - Porras, Carolina
AU - Rodriguez, Ana Cecilia
AU - Garmendia, Maria Luisa
AU - Soto, José Luis
AU - Moyano, Leonor
AU - Porter, Peggy L.
AU - Lin, Ming Gang
AU - Guenthoer, Jamie
AU - Romieu, Isabelle
AU - Rinaldi, Sabina
AU - Tejeda, Jenny
AU - Lazcano, María Felix
AU - Franco, Libia Zulema
AU - Jaramillo, Roberto
AU - Angel, Alberto
AU - Ossa, Carlos Andres
AU - Arias, William H.
AU - Bedoya, Gabriel
AU - Cock-Rada, Alicia
AU - Echeverri, Carolina
AU - Herazo, Fernando
AU - Díaz-Yunez, Israel
AU - Hernández, Angel
AU - Cortes, Bernal
AU - Gonzalez, Paula
AU - Ocampo, Rebecca
AU - Guillen, Diego
AU - Loría, Viviana
AU - Vial, Catalina
AU - Diaz, Lizette
AU - Donato, Elizabeth
AU - Donn, Thomas
AU - Wirtala, Kelly
AU - Loucks, Hailey
N1 - Publisher Copyright:
© 2022, The Author(s).
PY - 2022/12
Y1 - 2022/12
N2 - Background: Breast cancer incidence is increasing rapidly in Latin America, with a higher proportion of cases among young women than in developed countries. Studies have linked inflammation to breast cancer development, but data is limited in premenopausal women, especially in Latin America. Methods: We investigated the associations between serum biomarkers of chronic inflammation (interleukin (IL)-6, IL-8, IL-10, tumor necrosis factor-α (TNF-α), interferon-γ (IFN-γ), leptin, adiponectin) and risk of premenopausal breast cancer among 453 cases and 453 matched, population-based controls from Chile, Colombia, Costa Rica, and Mexico. Odds ratios (OR) were estimated using conditional logistic regression models. Analyses were stratified by size and hormonal receptor status of the tumors. Results: IL-6 (ORper standard deviation (SD) = 1.33 (1.11–1.60)) and TNF-α (ORper SD = 1.32 (1.11–1.58)) were positively associated with breast cancer risk in fully adjusted models. Evidence of heterogeneity by estrogen receptor (ER) status was observed for IL-8 (P-homogeneity = 0.05), with a positive association in ER-negative tumors only. IL-8 (P-homogeneity = 0.06) and TNF-α (P-homogeneity = 0.003) were positively associated with risk in the largest tumors, while for leptin (P-homogeneity = 0.003) a positive association was observed for the smallest tumors only. Conclusions: The results of this study support the implication of chronic inflammation in breast cancer risk in young women in Latin America. Largest studies of prospective design are needed to confirm these findings in premenopausal women.
AB - Background: Breast cancer incidence is increasing rapidly in Latin America, with a higher proportion of cases among young women than in developed countries. Studies have linked inflammation to breast cancer development, but data is limited in premenopausal women, especially in Latin America. Methods: We investigated the associations between serum biomarkers of chronic inflammation (interleukin (IL)-6, IL-8, IL-10, tumor necrosis factor-α (TNF-α), interferon-γ (IFN-γ), leptin, adiponectin) and risk of premenopausal breast cancer among 453 cases and 453 matched, population-based controls from Chile, Colombia, Costa Rica, and Mexico. Odds ratios (OR) were estimated using conditional logistic regression models. Analyses were stratified by size and hormonal receptor status of the tumors. Results: IL-6 (ORper standard deviation (SD) = 1.33 (1.11–1.60)) and TNF-α (ORper SD = 1.32 (1.11–1.58)) were positively associated with breast cancer risk in fully adjusted models. Evidence of heterogeneity by estrogen receptor (ER) status was observed for IL-8 (P-homogeneity = 0.05), with a positive association in ER-negative tumors only. IL-8 (P-homogeneity = 0.06) and TNF-α (P-homogeneity = 0.003) were positively associated with risk in the largest tumors, while for leptin (P-homogeneity = 0.003) a positive association was observed for the smallest tumors only. Conclusions: The results of this study support the implication of chronic inflammation in breast cancer risk in young women in Latin America. Largest studies of prospective design are needed to confirm these findings in premenopausal women.
KW - Biomarkers
KW - Breast cancer
KW - Inflammation
KW - Latin America
KW - Premenopausal
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U2 - 10.1186/s12885-022-09975-6
DO - 10.1186/s12885-022-09975-6
M3 - Article
C2 - 35948877
AN - SCOPUS:85136339637
SN - 1471-2407
VL - 22
JO - BMC cancer
JF - BMC cancer
IS - 1
M1 - 877
ER -