Abstract
Dysregulated interactions between host inflammation and gut microbiota over the course of life increase the risk of colorectal cancer (CRC). While environmental factors and socio-economic realities of race remain predominant contributors to CRC disparities in African-Americans (AAs), this review focuses on the biological mediators of CRC disparity, namely the under-appreciated influence of inherited ancestral genetic regulation on mucosal innate immunity and its interaction with the microbiome. There remains a poor understanding of mechanisms linking immune-related genetic polymorphisms and microbiome diversity that could influence chronic inflammation and exacerbate CRC disparities in AAs. A better understanding of the relationship between host genetics, bacteria, and CRC pathogenesis will improve the prediction of cancer risk across race/ethnicity groups overall.
Original language | English (US) |
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Pages (from-to) | 2782-2801 |
Number of pages | 20 |
Journal | World Journal of Gastroenterology |
Volume | 28 |
Issue number | 25 |
DOIs | |
State | Published - Jul 7 2022 |
Keywords
- African-American
- Colorectal cancer
- Inflammation
- Microbiome
- Minorities health
- Population-specific genome wide association studies
ASJC Scopus subject areas
- Gastroenterology