Inflammation, atrophy, and prostate carcinogenesis

Research output: Contribution to journalReview articlepeer-review

90 Scopus citations


The etiological agents that cause prostate cancer remain unknown. There is emerging evidence that "risk factor" lesions that are proposed to represent regenerative epithelium in response to environmental insults may precede the development of prostatic intraepithelial neoplasia and early carcinoma. Recent evidence suggests that these lesions, referred to collectively as proliferative inflammatory atrophy, may arise in the setting of inflammation and dietary toxins, such as "charred meat" carcinogens. Additional epidemiological, molecular pathological, and animal model work needs to be done to determine whether inflammation and atrophy are "driving" prostate carcinogenesis.

Original languageEnglish (US)
Pages (from-to)398-400
Number of pages3
JournalUrologic Oncology: Seminars and Original Investigations
Issue number5
StatePublished - Sep 2007


  • Atrophy
  • Inflammation
  • Prostate cancer

ASJC Scopus subject areas

  • Oncology
  • Urology


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