TY - JOUR
T1 - Inflammation and immune activation in antiretroviral-treated human immunodeficiency virus type 1-infected African infants and rotavirus vaccine responses
AU - Uprety, Priyanka
AU - Lindsey, Jane C.
AU - Levin, Myron J.
AU - Rainwater-Lovett, Kaitlin
AU - Ziemniak, Carrie
AU - Bwakura-Dangarembizix, Mutsa
AU - Kaplan, Susan S.
AU - Nelson, Micki
AU - Zadzilka, Amanda
AU - Weinberg, Adriana
AU - Persaud, Deborah
N1 - Funding Information:
This work was supported by grants to D. P. from the National Institutes of Health (NIH; RO1 HD080474) and the Johns Hopkins University Center for AIDS Research (P30AI094189). Overall support for the International Maternal Pediatric Adolescent AIDS Clinical Trials Group (IMPAACT) was provided by the National Institute of Allergy and Infectious Diseases of the NIH under award numbers UM1AI068632 (IMPAACT LOC), UM1AI068616 (IMPAACT SDMC), and UM1AI106716 (IMPAACT LC), with cofunding from the Eunice Kennedy Shriver National Institute of Child Health and Human Development and the National Institute of Mental Health.
Publisher Copyright:
© The Author 2017. Published by Oxford University Press for the Infectious Diseases Society of America.
PY - 2017/3/15
Y1 - 2017/3/15
N2 - Biomarkers of inflammation and immune activation were correlated with rotavirus vaccine responses in 68 human immunodeficiency virus type 1 (HIV-1)-infected (and 116 HIV-exposed but uninfected (HEU) African infants receiving pentavalent rotavirus vaccine (RV5) in a clinical trial. Prevaccination, HIV-1+ infants had significantly higher concentrations of interferon γ (IFNγ), interleukin1β, interleukin 2, interleukin 6, interleukin 10 (IL-10), and soluble CD14 compared with HEU infants. Postvaccination concentrations of neutralizing antibodies to RV5 were negatively correlated with prevaccination concentrations of IL-10 (RV5 surface proteins G1 and P1) and IFNγ (G1) in the HIV-1+ infants, whereas antirotavirus immunoglobulin A (IgA) levels were not. Heightened inflammation and immune activation in HIV-1+ infants did not alter IgA responses associated with protection from rotavirus disease.
AB - Biomarkers of inflammation and immune activation were correlated with rotavirus vaccine responses in 68 human immunodeficiency virus type 1 (HIV-1)-infected (and 116 HIV-exposed but uninfected (HEU) African infants receiving pentavalent rotavirus vaccine (RV5) in a clinical trial. Prevaccination, HIV-1+ infants had significantly higher concentrations of interferon γ (IFNγ), interleukin1β, interleukin 2, interleukin 6, interleukin 10 (IL-10), and soluble CD14 compared with HEU infants. Postvaccination concentrations of neutralizing antibodies to RV5 were negatively correlated with prevaccination concentrations of IL-10 (RV5 surface proteins G1 and P1) and IFNγ (G1) in the HIV-1+ infants, whereas antirotavirus immunoglobulin A (IgA) levels were not. Heightened inflammation and immune activation in HIV-1+ infants did not alter IgA responses associated with protection from rotavirus disease.
KW - Antiretroviral therapy
KW - Immune activation
KW - Inflammation
KW - Perinatal HIV-1 infection
KW - Rotavirus vaccine
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U2 - 10.1093/infdis/jix060
DO - 10.1093/infdis/jix060
M3 - Article
C2 - 28453843
AN - SCOPUS:85019713182
SN - 0022-1899
VL - 215
SP - 928
EP - 932
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 6
ER -