Induction Therapy in Pediatric Renal Transplant Recipients

Olga Charnaya, Asha Moudgil, Dechu Puliyanda

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Induction therapy to prevent acute rejection of mismatched allografts with the goal of prolonging the life of the allograft has been the cornerstone of immunosuppression since the beginning of renal transplantation. Agents used for induction have changed over time, and their role in transplantation has expanded to enable steroid avoidance and immunosuppression minimization. The choice of induction agent should be determined by an assessment of a patient’s individual immunological risk based on a combination of factors, including underlying kidney disease with possible high risk of recurrence, degree of allosensitization, risk for nonadherence, delayed graft function, and/or prolonged cold ischemic time. Induction in standard-risk and immunologically high-risk patients is discussed in this chapter.

Original languageEnglish (US)
Title of host publicationPediatric Solid Organ Transplantation
Subtitle of host publicationA Practical Handbook
PublisherSpringer Nature
Pages109-131
Number of pages23
ISBN (Electronic)9789811969096
ISBN (Print)9789811969089
DOIs
StatePublished - Jan 1 2023

Keywords

  • Acute rejection
  • Allosensitization
  • Induction immunosuppression
  • Kidney transplant
  • Lymphocyte depletion

ASJC Scopus subject areas

  • General Medicine

Fingerprint

Dive into the research topics of 'Induction Therapy in Pediatric Renal Transplant Recipients'. Together they form a unique fingerprint.

Cite this