TY - JOUR
T1 - Indoor particulate matter increases asthma morbidity in children with non-atopic and atopic asthma
AU - McCormack, Meredith C.
AU - Breysse, Patrick N.
AU - Matsui, Elizabeth C.
AU - Hansel, Nadia N.
AU - Peng, Roger D.
AU - Curtin-Brosnan, Jean
AU - Williams, D'Ann L.
AU - Wills-Karp, Marsha
AU - Diette, Gregory B.
PY - 2011/4
Y1 - 2011/4
N2 - Background: Compared with atopic asthma, fewer environmental modifications are recommended for non-atopic asthma in children. Objective: To better understand the role of indoor pollutants in provoking non-atopic asthma, we investigated the effect of in-home particulate matter on asthma symptoms among non-atopic and atopic children living in inner-city Baltimore. Methods: A cohort of 150 children ages 2 to 6 years with asthma underwent home environmental monitoring for 3-day intervals at baseline, 3, and 6 months. Children were classified as non-atopic if they were skin test negative to a panel of 14 aeroallergens. Caregivers completed questionnaires assessing symptoms and rescue medication use. Longitudinal data analysis included regression models with generalized estimating equations. Results: Children were primarily African American from lower socioeconomic backgrounds and spent most of their time in the home. Thirty-one percent were non-atopic, and 69% were atopic. Among non-atopic and atopic children, increased in-home fine (PM2.5) and coarse (PM2.5-10) particle concentrations were associated with significant increases in asthma symptoms and rescue medication use ranging from 7% (95% confidence interval [CI], 0-15) to 14% (95% CI, 1-27) per 10 μg/m 3 increase in particle concentration after adjustment for confounders. Conclusions: In-home particles similarly cause increased symptoms of asthma in non-atopic and atopic children. Environmental control strategies that reduce particle concentrations may prove to be an effective means of improving asthma outcomes, especially for non-atopic asthma, for which there are few environmental control practice recommendations.
AB - Background: Compared with atopic asthma, fewer environmental modifications are recommended for non-atopic asthma in children. Objective: To better understand the role of indoor pollutants in provoking non-atopic asthma, we investigated the effect of in-home particulate matter on asthma symptoms among non-atopic and atopic children living in inner-city Baltimore. Methods: A cohort of 150 children ages 2 to 6 years with asthma underwent home environmental monitoring for 3-day intervals at baseline, 3, and 6 months. Children were classified as non-atopic if they were skin test negative to a panel of 14 aeroallergens. Caregivers completed questionnaires assessing symptoms and rescue medication use. Longitudinal data analysis included regression models with generalized estimating equations. Results: Children were primarily African American from lower socioeconomic backgrounds and spent most of their time in the home. Thirty-one percent were non-atopic, and 69% were atopic. Among non-atopic and atopic children, increased in-home fine (PM2.5) and coarse (PM2.5-10) particle concentrations were associated with significant increases in asthma symptoms and rescue medication use ranging from 7% (95% confidence interval [CI], 0-15) to 14% (95% CI, 1-27) per 10 μg/m 3 increase in particle concentration after adjustment for confounders. Conclusions: In-home particles similarly cause increased symptoms of asthma in non-atopic and atopic children. Environmental control strategies that reduce particle concentrations may prove to be an effective means of improving asthma outcomes, especially for non-atopic asthma, for which there are few environmental control practice recommendations.
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U2 - 10.1016/j.anai.2011.01.015
DO - 10.1016/j.anai.2011.01.015
M3 - Article
C2 - 21457879
AN - SCOPUS:79953330771
SN - 1081-1206
VL - 106
SP - 308
EP - 315
JO - Annals of Allergy, Asthma and Immunology
JF - Annals of Allergy, Asthma and Immunology
IS - 4
ER -