TY - JOUR
T1 - Indoor Environmental Factors May Modify the Response to Mouse Allergen Reduction Among Mouse-Sensitized and Exposed Children with Persistent Asthma
AU - Sadreameli, S. Christy
AU - Ahmed, Ammara
AU - Curtin-Brosnan, Jean
AU - Perzanowski, Matthew S.
AU - Phipatanakul, Wanda
AU - Balcer-Whaley, Susan
AU - Divjan, Adnan
AU - Peng, Roger D.
AU - Newman, Michelle
AU - Cunningham, Amparito
AU - Bollinger, Mary E.
AU - Wise, Robert A.
AU - Miller, Rachel L.
AU - Matsui, Elizabeth C.
N1 - Funding Information:
This study was supported by the following National Institutes of Health grants: R01AI070630 , R01AI0818451 , P01ES018176 , 1P50ES015903 , M01-RR00052 , U01 Al 083238 , K24 AI 106822 , K24 AI114769 , R01 ES023447 , R01 ES026170 , P50ES015903 , P01 ES018176 , 5T32AI007007 , and K23HL138227 P30 ES09089 .
Publisher Copyright:
© 2021 American Academy of Allergy, Asthma & Immunology
PY - 2021/12
Y1 - 2021/12
N2 - Background: Whether concomitant home exposures modify the effectiveness of mouse allergen reduction among mouse-sensitized children with asthma is unknown. Objective: To determine whether a lower baseline home mouse allergen level, lower particulate matter 10 μ or less (PM10), and the absence of sensitization and exposure to other indoor allergens are associated with greater improvements in asthma associated with mouse allergen reduction. Methods: A secondary analysis of a randomized clinical trial of a home mouse allergen intervention was performed to examine the effect of 3 indoor factors on the relationship between mouse allergen reduction and a range of asthma outcomes. Results: Participants (N = 297) were predominantly minority (78% African American, 22% Hispanic) and publicly insured (88%). Higher baseline mouse allergen levels were associated with a greater response to mouse allergen reduction for several symptom and exacerbation outcomes. Lower indoor PM10 levels were associated with a greater response to mouse allergen reduction for several symptom outcomes, but not exacerbation outcomes. Overall, sensitization and exposure to other indoor allergens did not appear to modify the effect of mouse allergen reduction. Conclusions: In this population of predominantly low-income children with persistent asthma and mouse sensitization, mouse allergen reduction was associated with improvements in asthma, especially among those with high baseline mouse allergen exposure. Lower indoor PM10 was associated with greater improvements in asthma symptoms.
AB - Background: Whether concomitant home exposures modify the effectiveness of mouse allergen reduction among mouse-sensitized children with asthma is unknown. Objective: To determine whether a lower baseline home mouse allergen level, lower particulate matter 10 μ or less (PM10), and the absence of sensitization and exposure to other indoor allergens are associated with greater improvements in asthma associated with mouse allergen reduction. Methods: A secondary analysis of a randomized clinical trial of a home mouse allergen intervention was performed to examine the effect of 3 indoor factors on the relationship between mouse allergen reduction and a range of asthma outcomes. Results: Participants (N = 297) were predominantly minority (78% African American, 22% Hispanic) and publicly insured (88%). Higher baseline mouse allergen levels were associated with a greater response to mouse allergen reduction for several symptom and exacerbation outcomes. Lower indoor PM10 levels were associated with a greater response to mouse allergen reduction for several symptom outcomes, but not exacerbation outcomes. Overall, sensitization and exposure to other indoor allergens did not appear to modify the effect of mouse allergen reduction. Conclusions: In this population of predominantly low-income children with persistent asthma and mouse sensitization, mouse allergen reduction was associated with improvements in asthma, especially among those with high baseline mouse allergen exposure. Lower indoor PM10 was associated with greater improvements in asthma symptoms.
KW - Allergen exposure
KW - Allergen exposure reduction
KW - Allergic asthma
KW - Allergic sensitization
KW - PM
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U2 - 10.1016/j.jaip.2021.08.031
DO - 10.1016/j.jaip.2021.08.031
M3 - Article
C2 - 34506964
AN - SCOPUS:85115189768
SN - 2213-2198
VL - 9
SP - 4402-4409.e2
JO - Journal of Allergy and Clinical Immunology: In Practice
JF - Journal of Allergy and Clinical Immunology: In Practice
IS - 12
ER -