TY - JOUR
T1 - Indoor environmental exposures and obstructive lung disease phenotypes among children with asthma living in poor urban neighborhoods
AU - Grant, Torie
AU - Lilley, Travis
AU - McCormack, Meredith C.
AU - Rathouz, Paul J.
AU - Peng, Roger
AU - Keet, Corinne A.
AU - Rule, Ana
AU - Davis, Meghan
AU - Balcer-Whaley, Susan
AU - Newman, Michelle
AU - Matsui, Elizabeth C.
N1 - Funding Information:
Supported by the following sources: to T.G., National Institutes of Health (NIH) grant K23AI159144 and the American Academy of Allergy, Asthma & Immunology (AAAAI) Foundation Faculty Development Award; to M.M., NIH grant P50ES018176 and US Environmental Protection Agency (EPA) assistance agreement 83615201; to C.K., NIH grant U01AI125290 ; to M.D., NIH grant K01OD019918; and to E.M., NIH grants K24AI114769, R01ES023447, and R01ES026170. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH, AAAAI, or EPA.
Publisher Copyright:
© 2022 American Academy of Allergy, Asthma & Immunology
PY - 2023/3
Y1 - 2023/3
N2 - Background: Air trapping is an obstructive phenotype that has been associated with more severe and unstable asthma in children. Air trapping has been defined using pre- and postbronchodilator spirometry. The causes of air trapping are not completely understood. It is possible that environmental exposures could be implicated in air trapping in children with asthma. Objective: We investigated the association between indoor exposures and air trapping in urban children with asthma. Methods: Children with asthma aged 5 to 17 years living in Baltimore and enrolled onto the Environmental Control as Add-on Therapy for Childhood Asthma study were evaluated for air trapping using spirometry. Aeroallergen sensitization was assessed at baseline, and spirometry was performed at 0, 3, and 6 months. Air trapping was defined as an FVC z score of less than −1.64 or a change in FVC with bronchodilation of ≥10% predicted. Logistic normal random effects models were used to evaluate associations of air trapping and indoor exposures. Results: Airborne and bedroom floor mouse allergen concentrations were associated with air trapping but not airflow limitation (odds ratio 1.19, 95% confidence interval 1.02-1.37, P = .02 per 2-fold increase in airborne mouse allergen; odds ratio 1.23, 95% confidence interval 1.07-1.41, P = .003 per 2-fold increase in bedroom floor mouse allergen). Other indoor exposures (cockroach, cat, dog, dust mite, particulate matter, and nicotine) were not associated with air trapping or airflow limitation. Conclusion: Mouse allergen exposure, but not other indoor exposure, was associated with air trapping in urban children with asthma.
AB - Background: Air trapping is an obstructive phenotype that has been associated with more severe and unstable asthma in children. Air trapping has been defined using pre- and postbronchodilator spirometry. The causes of air trapping are not completely understood. It is possible that environmental exposures could be implicated in air trapping in children with asthma. Objective: We investigated the association between indoor exposures and air trapping in urban children with asthma. Methods: Children with asthma aged 5 to 17 years living in Baltimore and enrolled onto the Environmental Control as Add-on Therapy for Childhood Asthma study were evaluated for air trapping using spirometry. Aeroallergen sensitization was assessed at baseline, and spirometry was performed at 0, 3, and 6 months. Air trapping was defined as an FVC z score of less than −1.64 or a change in FVC with bronchodilation of ≥10% predicted. Logistic normal random effects models were used to evaluate associations of air trapping and indoor exposures. Results: Airborne and bedroom floor mouse allergen concentrations were associated with air trapping but not airflow limitation (odds ratio 1.19, 95% confidence interval 1.02-1.37, P = .02 per 2-fold increase in airborne mouse allergen; odds ratio 1.23, 95% confidence interval 1.07-1.41, P = .003 per 2-fold increase in bedroom floor mouse allergen). Other indoor exposures (cockroach, cat, dog, dust mite, particulate matter, and nicotine) were not associated with air trapping or airflow limitation. Conclusion: Mouse allergen exposure, but not other indoor exposure, was associated with air trapping in urban children with asthma.
KW - Pediatric asthma
KW - air trapping
KW - indoor environmental exposures
KW - mouse allergen exposure
KW - urban asthma
UR - http://www.scopus.com/inward/record.url?scp=85144446886&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85144446886&partnerID=8YFLogxK
U2 - 10.1016/j.jaci.2022.08.032
DO - 10.1016/j.jaci.2022.08.032
M3 - Article
C2 - 36395986
AN - SCOPUS:85144446886
SN - 0091-6749
VL - 151
SP - 716-722.e8
JO - Journal of Allergy and Clinical Immunology
JF - Journal of Allergy and Clinical Immunology
IS - 3
ER -