TY - JOUR
T1 - Individual participant data meta-analysis to compare EPDS accuracy to detect major depression with and without the self-harm item
AU - the Depression Screening Data (DEPRESSD) EPDS Group
AU - Qiu, Xia
AU - Wu, Yin
AU - Sun, Ying
AU - Levis, Brooke
AU - Tian, Jizhou
AU - Boruff, Jill T.
AU - Cuijpers, Pim
AU - Ioannidis, John P.A.
AU - Markham, Sarah
AU - Ziegelstein, Roy C.
AU - Vigod, Simone N.
AU - Benedetti, Andrea
AU - Thombs, Brett D.
AU - He, Chen
AU - Krishnan, Ankur
AU - Bhandari, Parash Mani
AU - Neupane, Dipika
AU - Negeri, Zelalem
AU - Imran, Mahrukh
AU - Rice, Danielle B.
AU - Azar, Marleine
AU - Chiovitti, Matthew J.
AU - Gilbody, Simon
AU - Kloda, Lorie A.
AU - Patten, Scott B.
AU - Mitchell, Nicholas D.
AU - Alvarado, Rubén
AU - Barnes, Jacqueline
AU - Beck, Cheryl Tatano
AU - Bindt, Carola
AU - Correa, Humberto
AU - Couto, Tiago Castro e.
AU - Chorwe-Sungani, Genesis
AU - Eapen, Valsamma
AU - Favez, Nicolas
AU - Felice, Ethel
AU - Fellmeth, Gracia
AU - Fernandes, Michelle
AU - Field, Sally
AU - Figueiredo, Barbara
AU - Fisher, Jane R.W.
AU - Green, Eric P.
AU - Honikman, Simone
AU - Howard, Louise M.
AU - Kettunen, Pirjo A.
AU - Kohlhoff, Jane
AU - Kozinszky, Zoltán
AU - Leonardou, Angeliki A.
AU - Maes, Michael
AU - Tandon, S. Darius
N1 - Publisher Copyright:
© 2023, The Author(s).
PY - 2023/12
Y1 - 2023/12
N2 - Item 10 of the Edinburgh Postnatal Depression Scale (EPDS) is intended to assess thoughts of intentional self-harm but may also elicit concerns about accidental self-harm. It does not specifically address suicide ideation but, nonetheless, is sometimes used as an indicator of suicidality. The 9-item version of the EPDS (EPDS-9), which omits item 10, is sometimes used in research due to concern about positive endorsements of item 10 and necessary follow-up. We assessed the equivalence of total score correlations and screening accuracy to detect major depression using the EPDS-9 versus full EPDS among pregnant and postpartum women. We searched Medline, Medline In-Process and Other Non-Indexed Citations, PsycINFO, and Web of Science from database inception to October 3, 2018 for studies that administered the EPDS and conducted diagnostic classification for major depression based on a validated semi-structured or fully structured interview among women aged 18 or older during pregnancy or within 12 months of giving birth. We conducted an individual participant data meta-analysis. We calculated Pearson correlations with 95% prediction interval (PI) between EPDS-9 and full EPDS total scores using a random effects model. Bivariate random-effects models were fitted to assess screening accuracy. Equivalence tests were done by comparing the confidence intervals (CIs) around the pooled sensitivity and specificity differences to the equivalence margin of δ = 0.05. Individual participant data were obtained from 41 eligible studies (10,906 participants, 1407 major depression cases). The correlation between EPDS-9 and full EPDS scores was 0.998 (95% PI 0.991, 0.999). For sensitivity, the EPDS-9 and full EPDS were equivalent for cut-offs 7–12 (difference range − 0.02, 0.01) and the equivalence was indeterminate for cut-offs 13–15 (all differences − 0.04). For specificity, the EPDS-9 and full EPDS were equivalent for all cut-offs (difference range 0.00, 0.01). The EPDS-9 performs similarly to the full EPDS and can be used when there are concerns about the implications of administering EPDS item 10. Trial registration: The original IPDMA was registered in PROSPERO (CRD42015024785).
AB - Item 10 of the Edinburgh Postnatal Depression Scale (EPDS) is intended to assess thoughts of intentional self-harm but may also elicit concerns about accidental self-harm. It does not specifically address suicide ideation but, nonetheless, is sometimes used as an indicator of suicidality. The 9-item version of the EPDS (EPDS-9), which omits item 10, is sometimes used in research due to concern about positive endorsements of item 10 and necessary follow-up. We assessed the equivalence of total score correlations and screening accuracy to detect major depression using the EPDS-9 versus full EPDS among pregnant and postpartum women. We searched Medline, Medline In-Process and Other Non-Indexed Citations, PsycINFO, and Web of Science from database inception to October 3, 2018 for studies that administered the EPDS and conducted diagnostic classification for major depression based on a validated semi-structured or fully structured interview among women aged 18 or older during pregnancy or within 12 months of giving birth. We conducted an individual participant data meta-analysis. We calculated Pearson correlations with 95% prediction interval (PI) between EPDS-9 and full EPDS total scores using a random effects model. Bivariate random-effects models were fitted to assess screening accuracy. Equivalence tests were done by comparing the confidence intervals (CIs) around the pooled sensitivity and specificity differences to the equivalence margin of δ = 0.05. Individual participant data were obtained from 41 eligible studies (10,906 participants, 1407 major depression cases). The correlation between EPDS-9 and full EPDS scores was 0.998 (95% PI 0.991, 0.999). For sensitivity, the EPDS-9 and full EPDS were equivalent for cut-offs 7–12 (difference range − 0.02, 0.01) and the equivalence was indeterminate for cut-offs 13–15 (all differences − 0.04). For specificity, the EPDS-9 and full EPDS were equivalent for all cut-offs (difference range 0.00, 0.01). The EPDS-9 performs similarly to the full EPDS and can be used when there are concerns about the implications of administering EPDS item 10. Trial registration: The original IPDMA was registered in PROSPERO (CRD42015024785).
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U2 - 10.1038/s41598-023-29114-w
DO - 10.1038/s41598-023-29114-w
M3 - Article
C2 - 36899016
AN - SCOPUS:85150003425
SN - 2045-2322
VL - 13
JO - Scientific reports
JF - Scientific reports
IS - 1
M1 - 4026
ER -