TY - JOUR
T1 - Indicators of platelet turnover in thrombocytopenic infants
AU - Sciscione, Anthony C.
AU - Bessos, Hagop
AU - Callan, Nancy
AU - Blakemore, Karin
AU - Kickler, Thomas
N1 - Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 1997/6
Y1 - 1997/6
N2 - Glycocalicin has been found to be a marker of increased platelet turnover, while interleukin-6 may be increased in response to thrombocytopenia. We used these markers to study the pathophysiology of thrombocytopenia in newborn infants. Cord blood platelet counts were obtained from 499 infants. Thrombocytopenic infants (< 100,000/mm3) and a control group had ELISA assays for interleukin-6 and glycocalicin performed. The mean levels of glycocalicin and interleukin-6 were elevated in cord blood of thrombocytopaenic infants. Infants with intrauterine growth restriction and thrombocytopaenia had no detectable glycocalicin in their plasma, despite elevated levels of interleukin-6. This probably reflects impaired thrombopoiesis in these infants.
AB - Glycocalicin has been found to be a marker of increased platelet turnover, while interleukin-6 may be increased in response to thrombocytopenia. We used these markers to study the pathophysiology of thrombocytopenia in newborn infants. Cord blood platelet counts were obtained from 499 infants. Thrombocytopenic infants (< 100,000/mm3) and a control group had ELISA assays for interleukin-6 and glycocalicin performed. The mean levels of glycocalicin and interleukin-6 were elevated in cord blood of thrombocytopaenic infants. Infants with intrauterine growth restriction and thrombocytopaenia had no detectable glycocalicin in their plasma, despite elevated levels of interleukin-6. This probably reflects impaired thrombopoiesis in these infants.
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U2 - 10.1111/j.1471-0528.1997.tb11990.x
DO - 10.1111/j.1471-0528.1997.tb11990.x
M3 - Article
C2 - 9197883
AN - SCOPUS:0030912699
SN - 1470-0328
VL - 104
SP - 743
EP - 745
JO - BJOG: An International Journal of Obstetrics and Gynaecology
JF - BJOG: An International Journal of Obstetrics and Gynaecology
IS - 6
ER -