Indications for the Use of Proton Pump Inhibitors for Stress Ulcer Prophylaxis and Peptic Ulcer Bleeding in Hospitalized Patients

Karen Clarke, Nicole Adler, Deepak Agrawal, Dimpal Bhakta, Suchita Shah Sata, Sarguni Singh, Arjun Gupta, Amit Pahwa, Emily Pherson, Alexander Sun, Frank Volpicelli, Hyung J. Cho

Research output: Contribution to journalReview articlepeer-review

Abstract

Proton pump inhibitors are widely used throughout the world for the treatment of gastrointestinal disorders that are related to acid secretion, such as peptic ulcer disease and dyspepsia. Another common indication for proton pump inhibitors is stress ulcer prophylaxis. Proton pump inhibitors have proven efficacy for the treatment of acid-related gastrointestinal disorders, but there is concern that their use may be associated with the development of significant complications, such as fractures, Clostridium difficile infection, acute kidney injury, chronic kidney disease, and hypomagnesemia. Proton pump inhibitors are overused in the hospital setting, both for stress ulcer prophylaxis and gastrointestinal bleeding, and then they are often inappropriately continued after discharge from the hospital. This narrative review article outlines the evidence surrounding appropriate proton pump inhibitor use for stress ulcer prophylaxis and peptic ulcer bleeding.

Original languageEnglish (US)
Pages (from-to)313-317
Number of pages5
JournalAmerican Journal of Medicine
Volume135
Issue number3
DOIs
StatePublished - Mar 2022

Keywords

  • Gastrointestinal bleed
  • Indications
  • Peptic ulcer
  • Proton pump inhibitor
  • Stress ulcer prophylaxis

ASJC Scopus subject areas

  • General Medicine

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