Independence of firing correlates of anatomically proximate hippocampal pyramidal cells.

A. D. Redish, F. P. Battaglia, M. K. Chawla, A. D. Ekstrom, J. L. Gerrard, P. Lipa, E. S. Rosenzweig, P. F. Worley, J. F. Guzowski, B. L. McNaughton, C. A. Barnes

Research output: Contribution to journalArticlepeer-review

97 Scopus citations


In neocortex, neighboring neurons frequently exhibit correlated encoding properties. There is conflicting evidence whether a similar phenomenon occurs in hippocampus. To assess this quantitatively, a comparison was made of the spatial and temporal firing correlations within and between local groups of hippocampal cells, spaced 350-1400 microm apart. No evidence of clustering was found in a sample of >3000 neurons. Moreover, cells active in two environments were uniformly interspersed at a scale of <100 microm, as assessed by the activity-induced gene Arc. Independence of encoding characteristics implies uncorrelated inputs, which could enhance the capacity of the hippocampus to store arbitrary associations.

Original languageEnglish (US)
Pages (from-to)RC134
JournalThe Journal of neuroscience : the official journal of the Society for Neuroscience
Issue number5
StatePublished - Mar 1 2001
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)


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