Increased Whole Blood Serotonin Concentrations in Chronic Schizophrenic Patients

Lynn E. DeLisi, Leonard M. Neckers, Daniel R. Weinberger, Richard Jed Wyatt

Research output: Contribution to journalArticlepeer-review

91 Scopus citations


Whole blood serotonin concentrations were studied in 33 chronic schizophrenic patients who previously had computed tomographic (CT) brain scans and in 23 healthy volunteers. The chronic schizophrenic patients had a mean serotonin concentration significantly higher than that of the controls. The patients were subcategorized into a group with abnormal CT scan findings (enlargement of cerebral ventricles, cerebral atrophy, or both) and a group with normal CT scans. The patients with abnormal CT scans had significantly higher serotonin concentrations when compared with schizophrenics with normal CT scans and with controls. The chronic schizophrenic patients with normal CT scans did not have significantly elevated serotonin concentrations compared with controls. Furthermore, ventricular size in the total patient group was significantly correlated with serotonin concentration.

Original languageEnglish (US)
Pages (from-to)647-650
Number of pages4
JournalArchives of general psychiatry
Issue number6
StatePublished - Jun 1981
Externally publishedYes

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Psychiatry and Mental health


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