Increased utilization of the hybrid procedure is not associated with improved early survival for newborns with hypoplastic left heart syndrome: a single-centre experience

Jonathan M. Chen, Richard F. Ittenbach, Kendall M. Lawrence, Mallory L. Hunt, Michelle Kaplinski, Marlene Mahle, Stephanie Fuller, Katsuhide Maeda, Muhammad A.K. Nuri, Monique M. Gardner, Constantine D. Mavroudis, Christopher E. Mascio, Thomas L. Spray, J. William Gaynor

Research output: Contribution to journalArticlepeer-review

Abstract

OBJECTIVES: The primary objectives were to examine utilization of the Hybrid versus the Norwood procedure for patients with hypoplastic left heart syndrome or variants and the impact on hospital mortality. The Hybrid procedure was 1st used at our institution in 2004. METHODS: Review of all subjects undergoing the Norwood or Hybrid procedure between 1 January 1984 and 31 December 2022. The study period was divided into 8 eras: era 1, 1984-1988; era 2, 1989-1993; era 3, 1994-1998; era 4, 1999-2003; era 5, 2004-2008; era 6, 2009-2014; era 7, 2015-2018 and era 8, 2019-2022. The primary outcome was in-hospital mortality. Mortality rates were computed using standard binomial proportions with 95% confidence intervals. Rates across eras were compared using an ordered logistic regression model with and adjusted using the Tukey-Kramer post-hoc procedure for multiple comparisons. In the risk-modelling phase, logistic regression models were specified and tested. RESULTS: The Norwood procedure was performed in 1899 subjects, and the Hybrid procedure in 82 subjects. Use of the Hybrid procedure increased in each subsequent era, reaching 30% of subjects in era 8. After adjustment for multiple risk factors, use of the Hybrid procedure was significantly and positively associated with hospital mortality. CONCLUSIONS: Despite the increasing use of the Hybrid procedure, overall mortality for the entire cohort has plateaued. After adjustment for risk factors, use of the Hybrid procedure was significantly and positively associated with mortality compared to the Norwood procedure.

Original languageEnglish (US)
Article numberezae164
JournalEuropean Journal of Cardio-thoracic Surgery
Volume65
Issue number4
DOIs
StatePublished - Apr 1 2024

Keywords

  • Congenital heart disease
  • Hybrid procedure
  • Hypoplastic left heart syndrome
  • Norwood procedure

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine

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