Increased temporal lobe glucose use in chronic schizophrenic patients

Lynn E. DeLisi; Monte S. Buchsbaum; Henry H. Holcomb; Katharine C. Langston; A. Catherine King; Robert Kessler; David Pickar; William T. Carpenter; John M. Morihisa; Richard Margolin; Daniel R. Weinberger

doi:10.1016/0006-3223(89)90263-1

Increased temporal lobe glucose use in chronic schizophrenic patients

Lynn E. DeLisi
, Monte S. Buchsbaum
, Henry H. Holcomb
, Katharine C. Langston
, A. Catherine King
, Robert Kessler
, David Pickar
, William T. Carpenter
, John M. Morihisa
, Richard Margolin
, Daniel R. Weinberger

Research output: Contribution to journal › Article › peer-review

113 Scopus citations

Abstract

Temporal lobe glucose metabolic rate was assessed in 21 off-medication patients with schizophrenia and 19 normal controls by positron emission tomography with ¹⁸F-deoxyglucose. Patients with schizophrenia had significantly greater metabolic activity in the left than the right anterior temporal lobe, and the extent of this lateralization was in proportion to the severity of psychopathology.

Original language	English (US)
Pages (from-to)	835-851
Number of pages	17
Journal	Biological psychiatry
Volume	25
Issue number	7
DOIs	https://doi.org/10.1016/0006-3223(89)90263-1
State	Published - Apr 1 1989
Externally published	Yes

ASJC Scopus subject areas

Biological Psychiatry

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10.1016/0006-3223(89)90263-1

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@article{c697894d1017496187586f8ae125ba7d,

title = "Increased temporal lobe glucose use in chronic schizophrenic patients",

abstract = "Temporal lobe glucose metabolic rate was assessed in 21 off-medication patients with schizophrenia and 19 normal controls by positron emission tomography with 18F-deoxyglucose. Patients with schizophrenia had significantly greater metabolic activity in the left than the right anterior temporal lobe, and the extent of this lateralization was in proportion to the severity of psychopathology.",

author = "DeLisi, \{Lynn E.\} and \{S. Buchsbaum\}, Monte and Holcomb, \{Henry H.\} and Langston, \{Katharine C.\} and King, \{A. Catherine\} and Robert Kessler and David Pickar and Carpenter, \{William T.\} and Morihisa, \{John M.\} and Richard Margolin and Weinberger, \{Daniel R.\}",

year = "1989",

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doi = "10.1016/0006-3223(89)90263-1",

language = "English (US)",

volume = "25",

pages = "835--851",

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TY - JOUR

T1 - Increased temporal lobe glucose use in chronic schizophrenic patients

AU - DeLisi, Lynn E.

AU - S. Buchsbaum, Monte

AU - Holcomb, Henry H.

AU - Langston, Katharine C.

AU - King, A. Catherine

AU - Kessler, Robert

AU - Pickar, David

AU - Carpenter, William T.

AU - Morihisa, John M.

AU - Margolin, Richard

AU - Weinberger, Daniel R.

PY - 1989/4/1

Y1 - 1989/4/1

N2 - Temporal lobe glucose metabolic rate was assessed in 21 off-medication patients with schizophrenia and 19 normal controls by positron emission tomography with 18F-deoxyglucose. Patients with schizophrenia had significantly greater metabolic activity in the left than the right anterior temporal lobe, and the extent of this lateralization was in proportion to the severity of psychopathology.

AB - Temporal lobe glucose metabolic rate was assessed in 21 off-medication patients with schizophrenia and 19 normal controls by positron emission tomography with 18F-deoxyglucose. Patients with schizophrenia had significantly greater metabolic activity in the left than the right anterior temporal lobe, and the extent of this lateralization was in proportion to the severity of psychopathology.

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UR - https://www.scopus.com/pages/publications/0024602019#tab=citedBy

U2 - 10.1016/0006-3223(89)90263-1

DO - 10.1016/0006-3223(89)90263-1

M3 - Article

C2 - 2785820

AN - SCOPUS:0024602019

SN - 0006-3223

VL - 25

SP - 835

EP - 851

JO - Biological psychiatry

JF - Biological psychiatry

IS - 7

ER -

Increased temporal lobe glucose use in chronic schizophrenic patients

Abstract

ASJC Scopus subject areas

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