Increased temporal lobe glucose use in chronic schizophrenic patients

Lynn E. DeLisi, Monte S. Buchsbaum, Henry H. Holcomb, Katharine C. Langston, A. Catherine King, Robert Kessler, David Pickar, William T. Carpenter, John M. Morihisa, Richard Margolin, Daniel R. Weinberger

Research output: Contribution to journalArticlepeer-review

113 Scopus citations


Temporal lobe glucose metabolic rate was assessed in 21 off-medication patients with schizophrenia and 19 normal controls by positron emission tomography with 18F-deoxyglucose. Patients with schizophrenia had significantly greater metabolic activity in the left than the right anterior temporal lobe, and the extent of this lateralization was in proportion to the severity of psychopathology.

Original languageEnglish (US)
Pages (from-to)835-851
Number of pages17
JournalBiological psychiatry
Issue number7
StatePublished - Apr 1 1989
Externally publishedYes

ASJC Scopus subject areas

  • Biological Psychiatry


Dive into the research topics of 'Increased temporal lobe glucose use in chronic schizophrenic patients'. Together they form a unique fingerprint.

Cite this