TY - JOUR
T1 - Increased serum HSP70 levels are associated with the duration of diabetes
AU - Nakhjavani, Manouchehr
AU - Morteza, Afsaneh
AU - Khajeali, Leila
AU - Esteghamati, Alireza
AU - Khalilzadeh, Omid
AU - Asgarani, Firouzeh
AU - Outeiro, Tiago F.
PY - 2010/11
Y1 - 2010/11
N2 - The evolutionary conserved family of heat shock proteins (HSP) is responsible for protecting cells against different types of stress, including oxidative stress. Although the levels of HSPs can be readily measured in blood serum, the levels of HSP70 in patients with different durations of diabetes have not been studied before. We quantified serum HSP70 levels in a healthy control group (n=36) and two groups of type 2 diabetic patients, defined as newly diagnosed diabetes (n=36) and patients with diabetes duration of more than 5 years (n=37). The clinical characteristics and biochemical parameters were evaluated in the studied population. We found that serum HSP70 levels were significantly higher in patients with diabetes when compared with controls (p<0.001) and it was higher in patients with disease for more than 5 years than in newly diagnosed patients (p<0.001). Serum HSP70 was inversely correlated with fasting blood sugar in patients with diabetes for more than 5 years (r=-0.500, p=0.002), positively correlated with the history of hypertension in newly diagnosed patients (p<0.001), and positively correlated with age in patients with diabetes (r=0.531, p=0.001). Serum level of HSP70 is significantly higher in patients with diabetes and correlates with the duration of disease. Higher HSP70 in prolonged diabetes versus newly diagnosed diabetes may be an indicator of metabolic derangement in the course of diabetes.
AB - The evolutionary conserved family of heat shock proteins (HSP) is responsible for protecting cells against different types of stress, including oxidative stress. Although the levels of HSPs can be readily measured in blood serum, the levels of HSP70 in patients with different durations of diabetes have not been studied before. We quantified serum HSP70 levels in a healthy control group (n=36) and two groups of type 2 diabetic patients, defined as newly diagnosed diabetes (n=36) and patients with diabetes duration of more than 5 years (n=37). The clinical characteristics and biochemical parameters were evaluated in the studied population. We found that serum HSP70 levels were significantly higher in patients with diabetes when compared with controls (p<0.001) and it was higher in patients with disease for more than 5 years than in newly diagnosed patients (p<0.001). Serum HSP70 was inversely correlated with fasting blood sugar in patients with diabetes for more than 5 years (r=-0.500, p=0.002), positively correlated with the history of hypertension in newly diagnosed patients (p<0.001), and positively correlated with age in patients with diabetes (r=0.531, p=0.001). Serum level of HSP70 is significantly higher in patients with diabetes and correlates with the duration of disease. Higher HSP70 in prolonged diabetes versus newly diagnosed diabetes may be an indicator of metabolic derangement in the course of diabetes.
KW - Diabetes duration
KW - HSP70
KW - Type2 diabetes
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U2 - 10.1007/s12192-010-0204-z
DO - 10.1007/s12192-010-0204-z
M3 - Article
C2 - 20496051
AN - SCOPUS:78149434868
SN - 1355-8145
VL - 15
SP - 959
EP - 964
JO - Cell Stress and Chaperones
JF - Cell Stress and Chaperones
IS - 6
ER -