Increased risk of xerophthalmia following diarrhea and respiratory disease

A. Sommer, I. Tarwotjo, J. Katz

Research output: Contribution to journalArticlepeer-review

65 Scopus citations


Preschool-age rural Indonesian children were reexamined every 3 mo for 18 mo. An average of 3228 were free of xerophthalmia at the examination initiating each of the six, 3-mo follow-up intervals. Children with respiratory disease and/or a recent history of diarrhea at the start of an interval developed xerophthalmia by the end of the interval at more than twice the rate of their healthier peers (p < 0.05) independent of anthropometric status. It appears that vitamin A deficiency and infections, especially diarrhea and respiratory disease, can establish a vicious cycle that induces and perpetuates ocular and systemic disease.

Original languageEnglish (US)
Pages (from-to)977-980
Number of pages4
JournalAmerican Journal of Clinical Nutrition
Issue number5
StatePublished - 1987

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics


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