Increased pulmonary pressures and myocardial wall stress in children with severe malaria

Jacqueline J. Janka, Ousmane A. Koita, Broulaye Traoré, Josépha M. Traoré, Fawaz Mzayek, Vandana Sachdev, Xunde Wang, Kassoum Sanogo, Lansana Sangaré, Laurel Masur, Henry Masur, Gregory J. Kato, Mark T. Gladwin, Donald J. Krogstad

Research output: Contribution to journalArticlepeer-review

42 Scopus citations


Background. Chronic intravascular hemolysis leads to nitric oxide (NO) depletion and pulmonary hypertension in sickle cell disease. To test whether this pathophysiology occurs in malaria, we examined in Mali 53 children who were admitted to the hospital with severe malaria (excluding cerebral malaria) and 31 age-matched controls. Methods. Severity of hemolysis was assessed from plasma levels of free hemoglobin and arginase-1. NO metabolism was assessed by whole-blood nitrite levels and plasma NO consumption. Effects on the cardiovascular system and endothelial function were assessed by using echocardiography to measure peak tricuspid regurgitant jet velocity and by evaluating plasma levels of N-terminal prohormone brain natriuretic peptide (NT-proBNP) and soluble vascular cell adhesion molecule-1. Results. Children with severe malaria had higher plasma levels of hemoglobin and arginase-1, reduced wholeblood levels of nitrite, and increased NO consumption relative to controls. They also had increased pulmonary arterial pressures ( P < .05) with elevated levels of NT-proBNP and soluble vascular cell adhesion molecule-P < .05 -1 (P < .001). Conclusion. Children with severe malaria have increased pulmonary pressures and myocardial wall stress. These complications are consistent with NO depletion from intravascular hemolysis, and they indicate that the pathophysiologic cascade from intravascular hemolysis to NO depletion and its cardiopulmonary effects is activated in children with severe malaria.

Original languageEnglish (US)
Pages (from-to)791-800
Number of pages10
JournalJournal of Infectious Diseases
Issue number5
StatePublished - Sep 1 2010
Externally publishedYes

ASJC Scopus subject areas

  • General Medicine


Dive into the research topics of 'Increased pulmonary pressures and myocardial wall stress in children with severe malaria'. Together they form a unique fingerprint.

Cite this