Increased protease-activated receptor 1 autoantibodies are associated with severe COVID-19

Florian Tran; Danielle M.M. Harris; Alena Scharmacher; Hanna Graßhoff; Kristina Sterner; Susanne Schinke; Nadja Käding; Jens Y. Humrich; Otávio Cabral-Marques; Joana P. Bernardes; Neha Mishra; Thomas Bahmer; Jeanette Franzenburg; Bimba F. Hoyer; Andreas Glück; Martina Guggeis; Alexander Ossysek; Andre Küller; Derk Frank; Christoph Lange; Jan Rupp; Jan Heyckendorf; Karoline I. Gaede; Howard Amital; Philip Rosenstiel; Yehuda Shoenfeld; Gilad Halpert; Avi Z. Rosenberg; Kai Schulze-Forster; Harald Heidecke; Gabriela Riemekasten; Stefan Schreiber

doi:10.1183/23120541.00379-2022

Increased protease-activated receptor 1 autoantibodies are associated with severe COVID-19

Florian Tran, Danielle M.M. Harris, Alena Scharmacher, Hanna Graßhoff, Kristina Sterner, Susanne Schinke, Nadja Käding, Jens Y. Humrich, Otávio Cabral-Marques, Joana P. Bernardes, Neha Mishra, Thomas Bahmer, Jeanette Franzenburg, Bimba F. Hoyer, Andreas Glück, Martina Guggeis, Alexander Ossysek, Andre Küller, Derk Frank, Christoph LangeJan Rupp, Jan Heyckendorf, Karoline I. Gaede, Howard Amital, Philip Rosenstiel, Yehuda Shoenfeld, Gilad Halpert, Avi Z. Rosenberg, Kai Schulze-Forster, Harald Heidecke, Gabriela Riemekasten, Stefan Schreiber

School of Medicine

Research output: Contribution to journal › Letter › peer-review

Original language	English (US)
Journal	ERJ Open Research
Volume	8
Issue number	4
DOIs	https://doi.org/10.1183/23120541.00379-2022
State	Published - 2022

Keywords

GPCR autoantibodies
Protease-activated receptor 1
Severe COVID-19
coagulation
disease outcome prediction

ASJC Scopus subject areas

Pulmonary and Respiratory Medicine

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10.1183/23120541.00379-2022

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Tran, F., Harris, D. M. M., Scharmacher, A., Graßhoff, H., Sterner, K., Schinke, S., Käding, N., Humrich, J. Y., Cabral-Marques, O., Bernardes, J. P., Mishra, N., Bahmer, T., Franzenburg, J., Hoyer, B. F., Glück, A., Guggeis, M., Ossysek, A., Küller, A., Frank, D., ... Schreiber, S. (2022). Increased protease-activated receptor 1 autoantibodies are associated with severe COVID-19. ERJ Open Research, 8(4). https://doi.org/10.1183/23120541.00379-2022

Tran, F, Harris, DMM, Scharmacher, A, Graßhoff, H, Sterner, K, Schinke, S, Käding, N, Humrich, JY, Cabral-Marques, O, Bernardes, JP, Mishra, N, Bahmer, T, Franzenburg, J, Hoyer, BF, Glück, A, Guggeis, M, Ossysek, A, Küller, A, Frank, D, Lange, C, Rupp, J, Heyckendorf, J, Gaede, KI, Amital, H, Rosenstiel, P, Shoenfeld, Y, Halpert, G, Rosenberg, AZ, Schulze-Forster, K, Heidecke, H, Riemekasten, G & Schreiber, S 2022, 'Increased protease-activated receptor 1 autoantibodies are associated with severe COVID-19', ERJ Open Research, vol. 8, no. 4. https://doi.org/10.1183/23120541.00379-2022

@article{f91de5687b98433f8ddf113a232b1651,

title = "Increased protease-activated receptor 1 autoantibodies are associated with severe COVID-19",

keywords = "GPCR autoantibodies, Protease-activated receptor 1, Severe COVID-19, coagulation, disease outcome prediction",

author = "Florian Tran and Harris, {Danielle M.M.} and Alena Scharmacher and Hanna Gra{\ss}hoff and Kristina Sterner and Susanne Schinke and Nadja K{\"a}ding and Humrich, {Jens Y.} and Ot{\'a}vio Cabral-Marques and Bernardes, {Joana P.} and Neha Mishra and Thomas Bahmer and Jeanette Franzenburg and Hoyer, {Bimba F.} and Andreas Gl{\"u}ck and Martina Guggeis and Alexander Ossysek and Andre K{\"u}ller and Derk Frank and Christoph Lange and Jan Rupp and Jan Heyckendorf and Gaede, {Karoline I.} and Howard Amital and Philip Rosenstiel and Yehuda Shoenfeld and Gilad Halpert and Rosenberg, {Avi Z.} and Kai Schulze-Forster and Harald Heidecke and Gabriela Riemekasten and Stefan Schreiber",

note = "Funding Information: We thank M. Rohm, M. Hansen and R. M{\"o}hring for perfect technical assistance. This work was supported by COVID-response grants of the state SH, ExC 2167 Precision Medicine in Chronic Inflammation (RTF-VI), the research group miTARGET and the BMBF iTREAT project to P.R, the IMI2 Project 3TR (P.R. and S.S.), EU projects SYSCID (733100 to P.R.). C.L. is supported by the German center for Infection Research (DZIF). The BioMaterialBank Nord is supported by the German Center for Lung Research (DZL), Airway Research Center North (ARCN). The BioMaterialBank Nord is member of popgen 2.0 network (P2N). We are indebted to the patients, their families and the hospital staff for support, without whom this study would not have been possible.",

year = "2022",

doi = "10.1183/23120541.00379-2022",

language = "English (US)",

volume = "8",

journal = "ERJ Open Research",

issn = "2312-0541",

publisher = "European Respiratory Society",

number = "4",

}

TY - JOUR

T1 - Increased protease-activated receptor 1 autoantibodies are associated with severe COVID-19

AU - Tran, Florian

AU - Harris, Danielle M.M.

AU - Scharmacher, Alena

AU - Graßhoff, Hanna

AU - Sterner, Kristina

AU - Schinke, Susanne

AU - Käding, Nadja

AU - Humrich, Jens Y.

AU - Cabral-Marques, Otávio

AU - Bernardes, Joana P.

AU - Mishra, Neha

AU - Bahmer, Thomas

AU - Franzenburg, Jeanette

AU - Hoyer, Bimba F.

AU - Glück, Andreas

AU - Guggeis, Martina

AU - Ossysek, Alexander

AU - Küller, Andre

AU - Frank, Derk

AU - Lange, Christoph

AU - Rupp, Jan

AU - Heyckendorf, Jan

AU - Gaede, Karoline I.

AU - Amital, Howard

AU - Rosenstiel, Philip

AU - Shoenfeld, Yehuda

AU - Halpert, Gilad

AU - Rosenberg, Avi Z.

AU - Schulze-Forster, Kai

AU - Heidecke, Harald

AU - Riemekasten, Gabriela

AU - Schreiber, Stefan

N1 - Funding Information: We thank M. Rohm, M. Hansen and R. Möhring for perfect technical assistance. This work was supported by COVID-response grants of the state SH, ExC 2167 Precision Medicine in Chronic Inflammation (RTF-VI), the research group miTARGET and the BMBF iTREAT project to P.R, the IMI2 Project 3TR (P.R. and S.S.), EU projects SYSCID (733100 to P.R.). C.L. is supported by the German center for Infection Research (DZIF). The BioMaterialBank Nord is supported by the German Center for Lung Research (DZL), Airway Research Center North (ARCN). The BioMaterialBank Nord is member of popgen 2.0 network (P2N). We are indebted to the patients, their families and the hospital staff for support, without whom this study would not have been possible.

PY - 2022

Y1 - 2022

KW - GPCR autoantibodies

KW - Protease-activated receptor 1

KW - Severe COVID-19

KW - coagulation

KW - disease outcome prediction

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U2 - 10.1183/23120541.00379-2022

DO - 10.1183/23120541.00379-2022

M3 - Letter

C2 - 36575710

AN - SCOPUS:85145065237

SN - 2312-0541

VL - 8

JO - ERJ Open Research

JF - ERJ Open Research

IS - 4

ER -

Increased protease-activated receptor 1 autoantibodies are associated with severe COVID-19

Keywords

ASJC Scopus subject areas

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