Increased neutrophil-to-lymphocyte ratio is associated with disease-specific mortality in patients with penile cancer

Jun Kasuga; Takashi Kawahara; Daiji Takamoto; Sachi Fukui; Takashi Tokita; Tomoyuki Tadenuma; Masaki Narahara; Syusei Fusayasu; Hideyuki Terao; Koji Izumi; Hiroki Ito; Yusuke Hattori; Jun Ichi Teranishi; Takeshi Sasaki; Kazuhide Makiyama; Yasuhide Miyoshi; Masahiro Yao; Yasushi Yumura; Hiroshi Miyamoto; Hiroji Uemura

doi:10.1186/s12885-016-2443-6

Increased neutrophil-to-lymphocyte ratio is associated with disease-specific mortality in patients with penile cancer

Jun Kasuga, Takashi Kawahara, Daiji Takamoto, Sachi Fukui, Takashi Tokita, Tomoyuki Tadenuma, Masaki Narahara, Syusei Fusayasu, Hideyuki Terao, Koji Izumi, Hiroki Ito, Yusuke Hattori, Jun Ichi Teranishi, Takeshi Sasaki, Kazuhide Makiyama, Yasuhide Miyoshi, Masahiro Yao, Yasushi Yumura, Hiroshi Miyamoto, Hiroji Uemura

School of Medicine

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Background: The neutrophil-to-lymphocyte ratio (NLR), a simple marker of the systemic inflammatory response, has been demonstrated to correlate with patient outcomes for various solid malignancies. We investigated the utility of the pretreatment NLR as a prognosticator in patients who presented with penile cancer. Methods: A total of 41 patients who underwent complete blood count with differential and subsequent radical penectomy from 1988 to 2014 were analyzed. We assessed the correlation between the NLR and the prognosis of penile cancer. Results: The median and mean (± SD) NLRs in 41 penile cancer patients were 3.42 and 5.03 ± 4.99, respectively. Based on the area under receiver operator characteristic curve, the cut-off value of NLR was determined to be 2.82. Patients with a high NLR (≥2.82) showed a significantly poorer cancer-specific survival (p = 0.023) than those with a low NLR. Conclusions: The pretreatment NLR may function as a biomarker that precisely predicts the prognosis in patients with penile cancer.

Original language	English (US)
Article number	396
Journal	BMC cancer
Volume	16
Issue number	1
DOIs	https://doi.org/10.1186/s12885-016-2443-6
State	Published - Jul 7 2016

Keywords

Biomarker
Immunohistochemistry
Neutrophil-to-lymphocyte ratio
Penile cancer

ASJC Scopus subject areas

Oncology
Genetics
Cancer Research

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10.1186/s12885-016-2443-6

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Kasuga, J., Kawahara, T., Takamoto, D., Fukui, S., Tokita, T., Tadenuma, T., Narahara, M., Fusayasu, S., Terao, H., Izumi, K., Ito, H., Hattori, Y., Teranishi, J. I., Sasaki, T., Makiyama, K., Miyoshi, Y., Yao, M., Yumura, Y., Miyamoto, H., & Uemura, H. (2016). Increased neutrophil-to-lymphocyte ratio is associated with disease-specific mortality in patients with penile cancer. BMC cancer, 16(1), Article 396. https://doi.org/10.1186/s12885-016-2443-6

Kasuga, J, Kawahara, T, Takamoto, D, Fukui, S, Tokita, T, Tadenuma, T, Narahara, M, Fusayasu, S, Terao, H, Izumi, K, Ito, H, Hattori, Y, Teranishi, JI, Sasaki, T, Makiyama, K, Miyoshi, Y, Yao, M, Yumura, Y, Miyamoto, H & Uemura, H 2016, 'Increased neutrophil-to-lymphocyte ratio is associated with disease-specific mortality in patients with penile cancer', BMC cancer, vol. 16, no. 1, 396. https://doi.org/10.1186/s12885-016-2443-6

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title = "Increased neutrophil-to-lymphocyte ratio is associated with disease-specific mortality in patients with penile cancer",

abstract = "Background: The neutrophil-to-lymphocyte ratio (NLR), a simple marker of the systemic inflammatory response, has been demonstrated to correlate with patient outcomes for various solid malignancies. We investigated the utility of the pretreatment NLR as a prognosticator in patients who presented with penile cancer. Methods: A total of 41 patients who underwent complete blood count with differential and subsequent radical penectomy from 1988 to 2014 were analyzed. We assessed the correlation between the NLR and the prognosis of penile cancer. Results: The median and mean (± SD) NLRs in 41 penile cancer patients were 3.42 and 5.03 ± 4.99, respectively. Based on the area under receiver operator characteristic curve, the cut-off value of NLR was determined to be 2.82. Patients with a high NLR (≥2.82) showed a significantly poorer cancer-specific survival (p = 0.023) than those with a low NLR. Conclusions: The pretreatment NLR may function as a biomarker that precisely predicts the prognosis in patients with penile cancer.",

keywords = "Biomarker, Immunohistochemistry, Neutrophil-to-lymphocyte ratio, Penile cancer",

author = "Jun Kasuga and Takashi Kawahara and Daiji Takamoto and Sachi Fukui and Takashi Tokita and Tomoyuki Tadenuma and Masaki Narahara and Syusei Fusayasu and Hideyuki Terao and Koji Izumi and Hiroki Ito and Yusuke Hattori and Teranishi, {Jun Ichi} and Takeshi Sasaki and Kazuhide Makiyama and Yasuhide Miyoshi and Masahiro Yao and Yasushi Yumura and Hiroshi Miyamoto and Hiroji Uemura",

note = "Funding Information: Grants from the Uehara Memorial Foundation, the Tokyo Biochemical Research Foundation, the Japanese Foundation for Research and Promotion of Endoscopy, and International exchange Grant from Kato Memorial Bioscience Foundation were provided to T.K. No grant numbers were applied. Publisher Copyright: {\textcopyright} 2016 The Author(s).",

year = "2016",

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doi = "10.1186/s12885-016-2443-6",

language = "English (US)",

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T1 - Increased neutrophil-to-lymphocyte ratio is associated with disease-specific mortality in patients with penile cancer

AU - Kasuga, Jun

AU - Kawahara, Takashi

AU - Takamoto, Daiji

AU - Fukui, Sachi

AU - Tokita, Takashi

AU - Tadenuma, Tomoyuki

AU - Narahara, Masaki

AU - Fusayasu, Syusei

AU - Terao, Hideyuki

AU - Izumi, Koji

AU - Ito, Hiroki

AU - Hattori, Yusuke

AU - Teranishi, Jun Ichi

AU - Sasaki, Takeshi

AU - Makiyama, Kazuhide

AU - Miyoshi, Yasuhide

AU - Yao, Masahiro

AU - Yumura, Yasushi

AU - Miyamoto, Hiroshi

AU - Uemura, Hiroji

N1 - Funding Information: Grants from the Uehara Memorial Foundation, the Tokyo Biochemical Research Foundation, the Japanese Foundation for Research and Promotion of Endoscopy, and International exchange Grant from Kato Memorial Bioscience Foundation were provided to T.K. No grant numbers were applied. Publisher Copyright: © 2016 The Author(s).

PY - 2016/7/7

Y1 - 2016/7/7

N2 - Background: The neutrophil-to-lymphocyte ratio (NLR), a simple marker of the systemic inflammatory response, has been demonstrated to correlate with patient outcomes for various solid malignancies. We investigated the utility of the pretreatment NLR as a prognosticator in patients who presented with penile cancer. Methods: A total of 41 patients who underwent complete blood count with differential and subsequent radical penectomy from 1988 to 2014 were analyzed. We assessed the correlation between the NLR and the prognosis of penile cancer. Results: The median and mean (± SD) NLRs in 41 penile cancer patients were 3.42 and 5.03 ± 4.99, respectively. Based on the area under receiver operator characteristic curve, the cut-off value of NLR was determined to be 2.82. Patients with a high NLR (≥2.82) showed a significantly poorer cancer-specific survival (p = 0.023) than those with a low NLR. Conclusions: The pretreatment NLR may function as a biomarker that precisely predicts the prognosis in patients with penile cancer.

AB - Background: The neutrophil-to-lymphocyte ratio (NLR), a simple marker of the systemic inflammatory response, has been demonstrated to correlate with patient outcomes for various solid malignancies. We investigated the utility of the pretreatment NLR as a prognosticator in patients who presented with penile cancer. Methods: A total of 41 patients who underwent complete blood count with differential and subsequent radical penectomy from 1988 to 2014 were analyzed. We assessed the correlation between the NLR and the prognosis of penile cancer. Results: The median and mean (± SD) NLRs in 41 penile cancer patients were 3.42 and 5.03 ± 4.99, respectively. Based on the area under receiver operator characteristic curve, the cut-off value of NLR was determined to be 2.82. Patients with a high NLR (≥2.82) showed a significantly poorer cancer-specific survival (p = 0.023) than those with a low NLR. Conclusions: The pretreatment NLR may function as a biomarker that precisely predicts the prognosis in patients with penile cancer.

KW - Biomarker

KW - Immunohistochemistry

KW - Neutrophil-to-lymphocyte ratio

KW - Penile cancer

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Increased neutrophil-to-lymphocyte ratio is associated with disease-specific mortality in patients with penile cancer

Abstract

Keywords

ASJC Scopus subject areas

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