TY - JOUR
T1 - Increased Mortality Associated With Vitamin A Deficiency During Human Immunodeficiency Virus Type 1 Infection
AU - Semba, Richard D.
AU - Graham, Neil M.H.
AU - Caiaffa, Waleska T.
AU - Margolick, Joseph B.
AU - Clement, Liliana
AU - Vlahov, David
N1 - Copyright:
Copyright 2015 Elsevier B.V., All rights reserved.
PY - 1993/9
Y1 - 1993/9
N2 - Objective: To determine whether plasma vitamin A levels are associated with immunologic status and clinical outcome during human immunodeficiency virus type 1 (HIV-1) infection. Patients and Patients and Methods: Analysis of vitamin A levels, CD4 T cells, complete blood cell count, and serologic markers for liver disease in a random subsample of 179 subjects from a cohort of more than 2000 intravenous drug users with longitudinal follow-up to determine survival. Results: Mean (±SE) follow-up time was 22.8±1.1 months, and 15 subjects died during follow-up. More than 15% of the HIV-l-seropositive individuals had plasma vitamin A levels less than 1.05 μmol/L, a level consistent with vitamin A deficiency. The HIV-l-seropositive individuals had lower mean plasma vitamin A levels than HIV-l-seronegative individuals (P<.001). Vitamin A deficiency was associated with lower CD4 levels among both seronegative individuals (P<.05) and seropositive individuals (P<.05). In the HIV-seropositive participants, vitamin A deficiency was associated with increased mortality (relative risk=6.3; 95% confidence interval, 2.1 to 18.6). Conclusion: Vitamin A deficiency may be common during HIV-1 infection, and vitamin A deficiency is associated with decreased circulating CD4 T cells and increased mortality. Vitamin A is an essential micronutrient for normal immune function, and vitamin A deficiency seems to be an important risk factor for disease progression during HIV-l infection.
AB - Objective: To determine whether plasma vitamin A levels are associated with immunologic status and clinical outcome during human immunodeficiency virus type 1 (HIV-1) infection. Patients and Patients and Methods: Analysis of vitamin A levels, CD4 T cells, complete blood cell count, and serologic markers for liver disease in a random subsample of 179 subjects from a cohort of more than 2000 intravenous drug users with longitudinal follow-up to determine survival. Results: Mean (±SE) follow-up time was 22.8±1.1 months, and 15 subjects died during follow-up. More than 15% of the HIV-l-seropositive individuals had plasma vitamin A levels less than 1.05 μmol/L, a level consistent with vitamin A deficiency. The HIV-l-seropositive individuals had lower mean plasma vitamin A levels than HIV-l-seronegative individuals (P<.001). Vitamin A deficiency was associated with lower CD4 levels among both seronegative individuals (P<.05) and seropositive individuals (P<.05). In the HIV-seropositive participants, vitamin A deficiency was associated with increased mortality (relative risk=6.3; 95% confidence interval, 2.1 to 18.6). Conclusion: Vitamin A deficiency may be common during HIV-1 infection, and vitamin A deficiency is associated with decreased circulating CD4 T cells and increased mortality. Vitamin A is an essential micronutrient for normal immune function, and vitamin A deficiency seems to be an important risk factor for disease progression during HIV-l infection.
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U2 - 10.1001/archinte.1993.00410180103012
DO - 10.1001/archinte.1993.00410180103012
M3 - Article
C2 - 8379807
AN - SCOPUS:0027437908
SN - 0003-9926
VL - 153
SP - 2149
EP - 2154
JO - Archives of internal medicine
JF - Archives of internal medicine
IS - 18
ER -