Increased levels of a mitochondrial DNA deletion in the brain of patients with bipolar disorder

Tadafumi Kato; O. Colin Stine; Francis J. McMahon; Raymond R. Crowe

doi:10.1016/S0006-3223(97)00012-7

Increased levels of a mitochondrial DNA deletion in the brain of patients with bipolar disorder

Tadafumi Kato, O. Colin Stine, Francis J. McMahon, Raymond R. Crowe

Research output: Contribution to journal › Article › peer-review

90 Scopus citations

Abstract

Mutations in mitochondrial DNA (mtDNA) have been implicated in the pathophysiology of affective disorders. To examine possible pathophysiological significance of mtDNA deletions in bipolar disorder, the concentration of the 4977-base-pair deletion in mtDNA in the autopsied brains of 7 patients with bipolar disorder, 9 suicide victims, and 9 controls was examined using a quantitative polymerase chain reaction method. The ratio of deleted to wild-type mtDNA in cerebral cortex was significantly higher in patients with bipolar disorder [0.23 ± 0.18 (mean ± SD)%] compared with that in age-matched controls (0.06 ± 0.07%, p < 0.05). This result supports a hypothesis that mtDNA deletions may play a role in the pathophysiology of bipolar disorder.

Original language	English (US)
Pages (from-to)	871-875
Number of pages	5
Journal	Biological psychiatry
Volume	42
Issue number	10
DOIs	https://doi.org/10.1016/S0006-3223(97)00012-7
State	Published - Nov 15 1997
Externally published	Yes

Keywords

Affective disorder
Depression
Energy metabolism
Molecular genetics
Mutation
Suicide

ASJC Scopus subject areas

Biological Psychiatry

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10.1016/S0006-3223(97)00012-7

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title = "Increased levels of a mitochondrial DNA deletion in the brain of patients with bipolar disorder",

abstract = "Mutations in mitochondrial DNA (mtDNA) have been implicated in the pathophysiology of affective disorders. To examine possible pathophysiological significance of mtDNA deletions in bipolar disorder, the concentration of the 4977-base-pair deletion in mtDNA in the autopsied brains of 7 patients with bipolar disorder, 9 suicide victims, and 9 controls was examined using a quantitative polymerase chain reaction method. The ratio of deleted to wild-type mtDNA in cerebral cortex was significantly higher in patients with bipolar disorder [0.23 ± 0.18 (mean ± SD)%] compared with that in age-matched controls (0.06 ± 0.07%, p < 0.05). This result supports a hypothesis that mtDNA deletions may play a role in the pathophysiology of bipolar disorder.",

keywords = "Affective disorder, Depression, Energy metabolism, Molecular genetics, Mutation, Suicide",

author = "Tadafumi Kato and Stine, {O. Colin} and McMahon, {Francis J.} and Crowe, {Raymond R.}",

note = "Funding Information: Supported in part by the Stanley Foundation Research Award, and The Research Grant (8B-2) for Nervous and Mental Disorders from the Ministry of Health and Welfare.",

year = "1997",

month = nov,

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doi = "10.1016/S0006-3223(97)00012-7",

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T1 - Increased levels of a mitochondrial DNA deletion in the brain of patients with bipolar disorder

AU - Kato, Tadafumi

AU - Stine, O. Colin

AU - McMahon, Francis J.

AU - Crowe, Raymond R.

N1 - Funding Information: Supported in part by the Stanley Foundation Research Award, and The Research Grant (8B-2) for Nervous and Mental Disorders from the Ministry of Health and Welfare.

PY - 1997/11/15

Y1 - 1997/11/15

N2 - Mutations in mitochondrial DNA (mtDNA) have been implicated in the pathophysiology of affective disorders. To examine possible pathophysiological significance of mtDNA deletions in bipolar disorder, the concentration of the 4977-base-pair deletion in mtDNA in the autopsied brains of 7 patients with bipolar disorder, 9 suicide victims, and 9 controls was examined using a quantitative polymerase chain reaction method. The ratio of deleted to wild-type mtDNA in cerebral cortex was significantly higher in patients with bipolar disorder [0.23 ± 0.18 (mean ± SD)%] compared with that in age-matched controls (0.06 ± 0.07%, p < 0.05). This result supports a hypothesis that mtDNA deletions may play a role in the pathophysiology of bipolar disorder.

AB - Mutations in mitochondrial DNA (mtDNA) have been implicated in the pathophysiology of affective disorders. To examine possible pathophysiological significance of mtDNA deletions in bipolar disorder, the concentration of the 4977-base-pair deletion in mtDNA in the autopsied brains of 7 patients with bipolar disorder, 9 suicide victims, and 9 controls was examined using a quantitative polymerase chain reaction method. The ratio of deleted to wild-type mtDNA in cerebral cortex was significantly higher in patients with bipolar disorder [0.23 ± 0.18 (mean ± SD)%] compared with that in age-matched controls (0.06 ± 0.07%, p < 0.05). This result supports a hypothesis that mtDNA deletions may play a role in the pathophysiology of bipolar disorder.

KW - Affective disorder

KW - Depression

KW - Energy metabolism

KW - Molecular genetics

KW - Mutation

KW - Suicide

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Increased levels of a mitochondrial DNA deletion in the brain of patients with bipolar disorder

Abstract

Keywords

ASJC Scopus subject areas

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