Increased frequencies of sister chromatid exchange in soldiers deployed to Kuwait

Melissa A. Mcdiarmid; David Jacobson-Kram; Ken Koloder; David P. Deeter; Richard M. Lachiver; Brian G. Scott; Bruno P. Petrucelli; David Gustavison; Donald Putman

doi:10.1093/mutage/10.3.263

Increased frequencies of sister chromatid exchange in soldiers deployed to Kuwait

Melissa A. Mcdiarmid, David Jacobson-Kram, Ken Koloder, David P. Deeter, Richard M. Lachiver, Brian G. Scott, Bruno P. Petrucelli, David Gustavison, Donald Putman

Bloomberg School of Public Health

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Frequencies of sister chromatid exchange (SCE), a measure of genotoxic exposure, were assessed in military troops deployed to Kuwait in 1991. Soldiers completed health questionnaires and had blood collected prior to, during and following deployment to Kuwait. Frequency of spontaneous SCE was determined on blood samples as a measure of mutagenic exposure. Compared to pre-deployment baseline SCE frequency means, levels obtained 2 months into the Kuwait deployment were significantly increased (P > 0.001) and persisted for at least 1 month after return to Germany. Outcome was unaffected by known personal SCE effect modifiers including smoking, age and diet. Potential sources of the apparent mutagenic exposure are discussed.

Original language	English (US)
Pages (from-to)	263-265
Number of pages	3
Journal	Mutagenesis
Volume	10
Issue number	3
DOIs	https://doi.org/10.1093/mutage/10.3.263
State	Published - May 1995

ASJC Scopus subject areas

Statistics, Probability and Uncertainty
Applied Mathematics
Health, Toxicology and Mutagenesis
Toxicology
Genetics(clinical)
Genetics

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10.1093/mutage/10.3.263

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title = "Increased frequencies of sister chromatid exchange in soldiers deployed to Kuwait",

abstract = "Frequencies of sister chromatid exchange (SCE), a measure of genotoxic exposure, were assessed in military troops deployed to Kuwait in 1991. Soldiers completed health questionnaires and had blood collected prior to, during and following deployment to Kuwait. Frequency of spontaneous SCE was determined on blood samples as a measure of mutagenic exposure. Compared to pre-deployment baseline SCE frequency means, levels obtained 2 months into the Kuwait deployment were significantly increased (P > 0.001) and persisted for at least 1 month after return to Germany. Outcome was unaffected by known personal SCE effect modifiers including smoking, age and diet. Potential sources of the apparent mutagenic exposure are discussed.",

author = "Mcdiarmid, {Melissa A.} and David Jacobson-Kram and Ken Koloder and Deeter, {David P.} and Lachiver, {Richard M.} and Scott, {Brian G.} and Petrucelli, {Bruno P.} and David Gustavison and Donald Putman",

year = "1995",

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T1 - Increased frequencies of sister chromatid exchange in soldiers deployed to Kuwait

AU - Mcdiarmid, Melissa A.

AU - Jacobson-Kram, David

AU - Koloder, Ken

AU - Deeter, David P.

AU - Lachiver, Richard M.

AU - Scott, Brian G.

AU - Petrucelli, Bruno P.

AU - Gustavison, David

AU - Putman, Donald

PY - 1995/5

Y1 - 1995/5

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AB - Frequencies of sister chromatid exchange (SCE), a measure of genotoxic exposure, were assessed in military troops deployed to Kuwait in 1991. Soldiers completed health questionnaires and had blood collected prior to, during and following deployment to Kuwait. Frequency of spontaneous SCE was determined on blood samples as a measure of mutagenic exposure. Compared to pre-deployment baseline SCE frequency means, levels obtained 2 months into the Kuwait deployment were significantly increased (P > 0.001) and persisted for at least 1 month after return to Germany. Outcome was unaffected by known personal SCE effect modifiers including smoking, age and diet. Potential sources of the apparent mutagenic exposure are discussed.

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Increased frequencies of sister chromatid exchange in soldiers deployed to Kuwait

Abstract

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