TY - JOUR
T1 - Incidence of ocular conditions associated with perfluoroalkyl substances exposure
T2 - Isomers of C8 Health Project in China
AU - Zeeshan, Mohammed
AU - Yang, Yunqing
AU - Zhou, Yang
AU - Huang, Wenzhong
AU - Wang, Zhibin
AU - Zeng, Xiao Yun
AU - Liu, Ru Qing
AU - Yang, Bo Yi
AU - Hu, Li Wen
AU - Zeng, Xiao Wen
AU - Sun, Xiao
AU - Yu, Yunjiang
AU - Dong, Guang Hui
N1 - Funding Information:
This study was funded by grants from the National Natural Science Foundation of China (No. 81950410633 , 81001255 , and 81673127 ), the National Key Research and Development Program of China (No. 2018YFE0106900 and 2018YFC1004300 ), the Science and Technology Planning Project of Guangdong Province (No. 2018B05052007 ), the Fundamental Research Funds for the Central Universities (No. 19ykjc01 ). The sponsor or funding organization had no role in the design or conduct of this research.
Publisher Copyright:
© 2020 The Authors
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/4
Y1 - 2020/4
N2 - The detrimental effects of perfluoroalkyl substances (PFASs) on several physiological systems have been reported, but the association of PFASs with eye, one of the most sensitive and exposed organ, has never been explored. To investigate the association between eye diseases including visual impairment (VI) and PFASs isomers, a cross-sectional stratified study was conducted in 1202 Chinese population, aged 22–96 years, from Shenyang, China. A standard protocol including Snellen vision chart, slit-lamp microscopy and direct ophthalmoscopy was used to examine eye diseases/conditions relating to anterior and posterior segment of eyes. In addition, we measured the blood concentrations of 19 linear and branched PFASs at one-time point. Results indicated that blood levels of PFASs were significantly higher in eye disease group than normal group. PFASs exposure were positively associated with both combined eye diseases and individual eye diseases. Among other PFASs, linear perfluorooctane sulfonate (n-PFOS; odds ratio [OR] = 3.37, 95% confidence interval [CI]: 2.50, 4.56), branched perfluorooctane sulfonate (Br-PFOS; OR = 2.25, 95% CI: 1.72, 2.93) and linear perfluorooctanoic acid (n-PFOA; OR = 1.79, 95% CI: 1.36, 2.37) significantly increases the odds of VI. Vitreous disorder was adversely associated with long-chain PFASs exposure. For example, perfluorotridecanoic acid (PFTrDA; OR = 1.86, 95% CI: 1.51, 2.29) and perfluorodecanoic acid (PFDA; OR = 1.79, 95% CI: 1.36, 2.36) showed the most significant association. In conclusion, this study suggests higher serum PFASs levels were associated with increase odds of VI and vitreous disorder in Chinese adults.
AB - The detrimental effects of perfluoroalkyl substances (PFASs) on several physiological systems have been reported, but the association of PFASs with eye, one of the most sensitive and exposed organ, has never been explored. To investigate the association between eye diseases including visual impairment (VI) and PFASs isomers, a cross-sectional stratified study was conducted in 1202 Chinese population, aged 22–96 years, from Shenyang, China. A standard protocol including Snellen vision chart, slit-lamp microscopy and direct ophthalmoscopy was used to examine eye diseases/conditions relating to anterior and posterior segment of eyes. In addition, we measured the blood concentrations of 19 linear and branched PFASs at one-time point. Results indicated that blood levels of PFASs were significantly higher in eye disease group than normal group. PFASs exposure were positively associated with both combined eye diseases and individual eye diseases. Among other PFASs, linear perfluorooctane sulfonate (n-PFOS; odds ratio [OR] = 3.37, 95% confidence interval [CI]: 2.50, 4.56), branched perfluorooctane sulfonate (Br-PFOS; OR = 2.25, 95% CI: 1.72, 2.93) and linear perfluorooctanoic acid (n-PFOA; OR = 1.79, 95% CI: 1.36, 2.37) significantly increases the odds of VI. Vitreous disorder was adversely associated with long-chain PFASs exposure. For example, perfluorotridecanoic acid (PFTrDA; OR = 1.86, 95% CI: 1.51, 2.29) and perfluorodecanoic acid (PFDA; OR = 1.79, 95% CI: 1.36, 2.36) showed the most significant association. In conclusion, this study suggests higher serum PFASs levels were associated with increase odds of VI and vitreous disorder in Chinese adults.
KW - Eye diseases
KW - PFASs isomers
KW - Perfluoroalkyl substances (PFASs)
KW - Visual impairment
KW - Vitreous disorder
UR - http://www.scopus.com/inward/record.url?scp=85079179552&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85079179552&partnerID=8YFLogxK
U2 - 10.1016/j.envint.2020.105555
DO - 10.1016/j.envint.2020.105555
M3 - Article
C2 - 32059142
AN - SCOPUS:85079179552
SN - 0160-4120
VL - 137
JO - Environmental International
JF - Environmental International
M1 - 105555
ER -