TY - JOUR
T1 - Incidence and Clinical Characteristics of Ocular Involvement in Mucous Membrane Pemphigoid
AU - Hong, Gloria H.
AU - Khan, Irfan
AU - Shifera, Amde Selassie
AU - Okeagu, Chinwenwa
AU - Thorne, Jennifer E.
N1 - Publisher Copyright:
© 2019, © 2019 Taylor & Francis Group, LLC.
PY - 2019
Y1 - 2019
N2 - Purpose: To describe the risk of developing ocular mucous membrane pemphigoid (MMP) or a new extraocular site of MMP, and to identify risk factors for new involvement. Methods: Retrospective chart review of 162 biopsy-proven MMP patients. Results: At presentation, 109 of 162 MMP patients (67.3%) had ocular involvement and 53 patients did not. Of the 53 patients without ocular involvement at presentation followed up to 22 years, the risk of developing ocular MMP was 0.014 per person-year (PY, 95% confidence interval [CI]: 0.005/PY, 0.034/PY). The risk of developing any new location of extraocular MMP was 0.020/PY (95% CI: 0.007/PY, 0.043/PY). Smoking was a risk factor for developing an additional extraocular MMP location (hazard ratio [HR] = 4.09, p = 0.04). Conclusions: Patients presenting with extraocular MMP are at risk for developing ocular MMP, and all MMP patients are at risk for developing secondary extraocular MMP locations, although the rates were low.
AB - Purpose: To describe the risk of developing ocular mucous membrane pemphigoid (MMP) or a new extraocular site of MMP, and to identify risk factors for new involvement. Methods: Retrospective chart review of 162 biopsy-proven MMP patients. Results: At presentation, 109 of 162 MMP patients (67.3%) had ocular involvement and 53 patients did not. Of the 53 patients without ocular involvement at presentation followed up to 22 years, the risk of developing ocular MMP was 0.014 per person-year (PY, 95% confidence interval [CI]: 0.005/PY, 0.034/PY). The risk of developing any new location of extraocular MMP was 0.020/PY (95% CI: 0.007/PY, 0.043/PY). Smoking was a risk factor for developing an additional extraocular MMP location (hazard ratio [HR] = 4.09, p = 0.04). Conclusions: Patients presenting with extraocular MMP are at risk for developing ocular MMP, and all MMP patients are at risk for developing secondary extraocular MMP locations, although the rates were low.
KW - Cicatrizing conjunctivitis
KW - incidence rates
KW - ocular cicatricial
KW - ocular mucous membrane pemphigoid
KW - pemphigoid
KW - risk factors
UR - http://www.scopus.com/inward/record.url?scp=85045732397&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85045732397&partnerID=8YFLogxK
U2 - 10.1080/09273948.2018.1455879
DO - 10.1080/09273948.2018.1455879
M3 - Article
C2 - 29672212
AN - SCOPUS:85045732397
SN - 0927-3948
VL - 27
SP - 821
EP - 825
JO - Ocular Immunology and Inflammation
JF - Ocular Immunology and Inflammation
IS - 5
ER -