In vivo magnetic resonance spectroscopy of GABA: A methodological review

Nicolaas Puts, Richard A.E. Edden

Research output: Contribution to journalReview articlepeer-review

210 Scopus citations


A study was conducted to demonstrate a methodological review of in vivo magnetic resonance spectroscopy (MRS) of GABA. Investigations revealed that two main sub-types of GABA receptor, such as GABA A and GABA B mediated the synaptic effects of GABA, and synaptic GABA was rapidly removed by high-affinity GABA transporters (GAT). GABA was produced from glutamate by glutamic acid decarboxylase (GAD) within GABAergic neurons and was metabolized to succinic acid semialdehyde by GABA transaminase (GABA-T) and to succinate within astrocytic mitochondria. MRS involved the in vivo application of nuclear magnetic resonance (NMR) spectroscopy and was implemented on magnetic resonance imaging (MRI) scanners. MRS signals were separated in the MR spectrum along chemical lines, known as the chemical shift dimension.

Original languageEnglish (US)
Pages (from-to)29-41
Number of pages13
JournalProgress in Nuclear Magnetic Resonance Spectroscopy
StatePublished - Jan 2012


  • GABA
  • Inhibition
  • J-difference editing
  • MRS

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Nuclear and High Energy Physics
  • Spectroscopy


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