TY - JOUR
T1 - In vivo imaging of phosphocreatine with artificial neural networks
AU - Chen, Lin
AU - Schär, Michael
AU - Chan, Kannie W.Y.
AU - Huang, Jianpan
AU - Wei, Zhiliang
AU - Lu, Hanzhang
AU - Qin, Qin
AU - Weiss, Robert G.
AU - van Zijl, Peter C.M.
AU - Xu, Jiadi
N1 - Funding Information:
This work was supported by National Institutes of Health grants R01EB015032, P41EB015909, R01HL61912, R01HL63030, R03NS109664, and DOD W81XWH-18-1-0797. The 3 T human MRI equipment in this study was funded by NIH grant 1S10OD021648. We thank Tricia Steinberg for assisting in the in-magnet plantar flexion exercise study.
Publisher Copyright:
© 2020, The Author(s).
PY - 2020/12/1
Y1 - 2020/12/1
N2 - Phosphocreatine (PCr) plays a vital role in neuron and myocyte energy homeostasis. Currently, there are no routine diagnostic tests to noninvasively map PCr distribution with clinically relevant spatial resolution and scan time. Here, we demonstrate that artificial neural network-based chemical exchange saturation transfer (ANNCEST) can be used to rapidly quantify PCr concentration with robust immunity to commonly seen MRI interferences. High-quality PCr mapping of human skeletal muscle, as well as the information of exchange rate, magnetic field and radio-frequency transmission inhomogeneities, can be obtained within 1.5 min on a 3 T standard MRI scanner using ANNCEST. For further validation, we apply ANNCEST to measure the PCr concentrations in exercised skeletal muscle. The ANNCEST outcomes strongly correlate with those from 31P magnetic resonance spectroscopy (R = 0.813, p < 0.001, t test). These results suggest that ANNCEST has potential as a cost-effective and widely available method for measuring PCr and diagnosing related diseases.
AB - Phosphocreatine (PCr) plays a vital role in neuron and myocyte energy homeostasis. Currently, there are no routine diagnostic tests to noninvasively map PCr distribution with clinically relevant spatial resolution and scan time. Here, we demonstrate that artificial neural network-based chemical exchange saturation transfer (ANNCEST) can be used to rapidly quantify PCr concentration with robust immunity to commonly seen MRI interferences. High-quality PCr mapping of human skeletal muscle, as well as the information of exchange rate, magnetic field and radio-frequency transmission inhomogeneities, can be obtained within 1.5 min on a 3 T standard MRI scanner using ANNCEST. For further validation, we apply ANNCEST to measure the PCr concentrations in exercised skeletal muscle. The ANNCEST outcomes strongly correlate with those from 31P magnetic resonance spectroscopy (R = 0.813, p < 0.001, t test). These results suggest that ANNCEST has potential as a cost-effective and widely available method for measuring PCr and diagnosing related diseases.
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U2 - 10.1038/s41467-020-14874-0
DO - 10.1038/s41467-020-14874-0
M3 - Article
C2 - 32102999
AN - SCOPUS:85080085400
SN - 2041-1723
VL - 11
JO - Nature communications
JF - Nature communications
IS - 1
M1 - 1072
ER -