In Vivo Evaluation of a Noninvasive Method to Measure the Retinal Thickness in Primates

Ran C. Zeimer, Mahnaz Shahidi, Marek T. Mori, Elias Benhamou

Research output: Contribution to journalArticlepeer-review

23 Scopus citations


To diagnose certain macular diseases earlier and monitor their therapy more sensitively, we are developing a noninvasive method to measure the retinal thickness. The new instrument, which is an extension of slit-lamp biomicroscopy, was used to obtain the data, which were analyzed with an algorithm to yield thickness measurements. The measurements performed in monkeys indicated that the retinal thickness can be visualized in a region extending from the optic disc to the fovea and that quantitative results can be obtained. The retinal thickness reproducibility was 6% for the same location on the same day, 15% for the same location on different days, and 12% for the same location in different eyes. The average retinal thickness in these areas was 335 μm, indicating that the reproducibility was between 20 and 50 μm. Measurements across the foveola illustrated that retinal thicknesses as low as 80 μm could be obtained.

Original languageEnglish (US)
Pages (from-to)1006-1009
Number of pages4
JournalArchives of ophthalmology
Issue number7
StatePublished - Jul 1989
Externally publishedYes

ASJC Scopus subject areas

  • Ophthalmology


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