In vivo and in vitro MR spectroscopic profile of central neurocytomas

Rama Jayasundar, Tariq Shah, Sandeep Vaishya, Virender P. Singh, Chitra Sarkar

Research output: Contribution to journalArticlepeer-review

35 Scopus citations


This study reports in vivo and in vitro magnetic resonance spectroscopic findings in two cases of central neurocytomas (CNC) confirmed by immunohistochemistry. Volume localized in vivo proton magnetic resonance spectroscopy (MRS) was carried out before surgery using a point resolved spectroscopy (PRESS) sequence with a repetition time of six seconds and an echo time of 135 msec. Normal spectrum was obtained from gray matter from a volunteer for comparison. 1H and 31P in vitro MRS studies were carried out at 9.4 T on the extracts prepared from the surgically excised tumors. The in vivo spectra showed prominent glycine (Gly) and choline (Cho) and low N-acetyl aspartate compared to the normal. The Gly peak was assigned using the in vitro studies. These studies showed that the major contribution to the Cho peak observed in vivo is from phosphocholine. A combination of the presence of NAA and an increased Gly in the proton MR spectrum could be a characteristic feature of CNCs, which are rare intraventricular tumors of neuronal origin.

Original languageEnglish (US)
Pages (from-to)256-260
Number of pages5
JournalJournal of Magnetic Resonance Imaging
Issue number2
StatePublished - Feb 1 2003
Externally publishedYes


  • Central neurocytoma (CNC)
  • Glycine
  • Intraventricular tumor
  • Magnetic resonance spectroscopy (MRS)
  • N-acetylaspartate (NAA)

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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